气候变化领域集成服务门户(CCPortal): Resetting histone modifications during human parental-to-zygotic transition

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DOI	10.1126/science.aaw5118
	Resetting histone modifications during human parental-to-zygotic transition
	Xia W.; Xu J.; Yu G.; Yao G.; Xu K.; Ma X.; Zhang N.; Liu B.; Li T.; Lin Z.; Chen X.; Li L.; Wang Q.; Shi D.; Shi S.; Zhang Y.; Song W.; Jin H.; Hu L.; Bu Z.; Wang Y.; Na J.; Xie W.; Sun Y.-P.
发表日期	2019
ISSN	0036-8075
起始页码	353
结束页码	360
卷号	365 期号:6451
英文摘要	Histone modifications regulate gene expression and development. To address how they are reprogrammed in human early development, we investigated key histone marks in human oocytes and early embryos. Unlike that in mouse oocytes, the permissive mark trimethylated histone H3 lysine 4 (H3K4me3) largely exhibits canonical patterns at promoters in human oocytes. After fertilization, prezygotic genome activation (pre-ZGA) embryos acquire permissive chromatin and widespread H3K4me3 in CpG-rich regulatory regions. By contrast, the repressive mark H3K27me3 undergoes global depletion. CpG-rich regulatory regions then resolve to either active or repressed states upon ZGA, followed by subsequent restoration of H3K27me3 at developmental genes. Finally, by combining chromatin and transcriptome maps, we revealed transcription circuitry and asymmetric H3K27me3 patterning during early lineage specification. Collectively, our data unveil a priming phase connecting human parental-to-zygotic epigenetic transition. © 2019 American Association for the Advancement of Science. All rights reserved.
英文关键词	histone; transcriptome; histone; transcriptome; developmental biology; gene; gene expression; genome; protein; allele; Article; chromatin; controlled study; CpG island; developmental gene; developmental stage; embryo; epigenetics; female; fertilization; gene activation; gene mapping; genetic transcription; genome; genome imprinting; histone methylation; human; human cell; human tissue; oocyte; priority journal; promoter region; zygote; animal; blastocyst; genetic epigenesis; histone code; metabolism; mouse; zygote; Animals; Blastocyst; Chromatin; CpG Islands; Epigenesis, Genetic; Histone Code; Histones; Humans; Mice; Oocytes; Transcriptome; Zygote
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/246073
作者单位	Center for Stem Cell Biology and Regenerative Medicine, MOE Key Laboratory of Bioinformatics, THU-PKU Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, 100084, China; Center for Reproductive Medicine, Henan Key Laboratory of Reproduction and Genetics, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China; Center for Stem Cell Biology and Regenerative Medicine, School of Medicine, Tsinghua University, Beijing, 100084, China
推荐引用方式 GB/T 7714	Xia W.,Xu J.,Yu G.,et al. Resetting histone modifications during human parental-to-zygotic transition[J],2019,365(6451).
APA	Xia W..,Xu J..,Yu G..,Yao G..,Xu K..,...&Sun Y.-P..(2019).Resetting histone modifications during human parental-to-zygotic transition.Science,365(6451).
MLA	Xia W.,et al."Resetting histone modifications during human parental-to-zygotic transition".Science 365.6451(2019).