气候变化领域集成服务门户(CCPortal): A year of genomic surveillance reveals how the SARS-CoV-2 pandemic unfolded in Africa

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DOI	10.1126/science.abj4336
	A year of genomic surveillance reveals how the SARS-CoV-2 pandemic unfolded in Africa
	Wilkinson E.; Giovanetti M.; Tegally H.; San J.E.; Lessells R.; Cuadros D.; Martin D.P.; Rasmussen D.A.; Zekri A.-R.N.; Sangare A.K.; Ouedraogo A.-S.; Sesay A.K.; Priscilla A.; Kemi A.-S.; Olubusuyi A.M.; Oluwapelumi A.O.O.; Hammami A.; Amuri A.A.; Sayed A.; Ouma A.E.O.; Elargoubi A.; Ajayi N.A.; Victoria A.F.; Kazeem A.; George A.; Trotter A.J.; Yahaya A.A.; Keita A.K.; Diallo A.; Kone A.; Souissi A.; Chtourou A.; Gutierrez A.V.; Page A.J.; Vinze A.; Iranzadeh A.; Lambisia A.; Ismail A.; Rosemary A.; Sylverken A.; Femi A.; Ibrahimi A.; Marycelin B.; Oderinde B.S.; Bolajoko B.; Dhaala B.; Herring B.L.; Njanpop-Lafourcade B.-M.; Kleinhans B.; McInnis B.; Tegomoh B.; Brook C.; Pratt C.B.; Scheepers C.; Akoua-Koffi C.G.; Agoti C.N.; Peyrefitte C.; Daubenberger C.; Morang’a C.M.; James Nokes D.; Amoako D.G.; Bugembe D.L.; Park D.; Baker D.; Doolabh D.; Ssemwanga D.; Tshiabuila D.; Bassirou D.; Amuzu D.S.Y.; Goedhals D.; Omuoyo D.O.; Maruapula D.; Foster-Nyarko E.; Lusamaki E.K.; Simulundu E.; Ong’era E.M.; Ngabana E.N.; Shumba E.; El Fahime E.; Lokilo E.; Mukantwari E.; Philomena E.; Belarbi E.; Simon-Loriere E.; Anoh E.A.; Leendertz F.; Ajili F.; Enoch F.O.; Wasfi F.; Abdelmoula F.; Mosha F.S.; Takawira F.T.; Derrar F.; Bouzid F.; Onikepe F.; Adeola F.; Muyembe F.M.; Tanser F.; Dratibi F.A.; Mbunsu G.K.; Thilliez G.; Kay G.L.; Githinji G.; van Zyl G.; Awandare G.A.; Schubert G.; Maphalala G.P.; Ranaivoson H.C.; Lemriss H.; Anise H.; Abe H.; Karray H.H.; Nansumba H.; Elgahzaly H.A.; Gumbo H.; Smeti I.; Ayed I.B.; Odia I.; Boubaker I.B.B.; Gaaloul I.; Gazy I.; Mudau I.; Ssewanyana I.; Konstantinus I.; Lekana-Douk J.B.; Makangara J.-C.C.; Tamfum J.-J.M.; Heraud J.-M.; Shaffer J.G.; Giandhari J.; Li J.; Yasuda J.; Mends J.Q.; Kiconco J.; Morobe J.M.; Gyapong J.O.; Okolie J.C.; Kayiwa J.T.; Edwards J.A.; Gyamfi J.; Farah J.; Nakaseegu J.; Ngoi J.M.; Namulondo J.; Andeko J.C.; Lutwama J.J.; O’Grady J.; Siddle K.; Adeyemi K.T.; Tumedi K.A.; Said K.M.; Hae-Young K.; Duedu K.O.; Belyamani L.; Fki-Berrajah L.; Singh L.; Martins L.D.O.; Tyers L.; Ramuth M.; Mastouri M.; Aouni M.; el Hefnawi M.; Matsheka M.I.; Kebabonye M.; Diop M.; Turki M.; Paye M.; Nyaga M.M.; Mareka M.; Damaris M.-M.; Mburu M.W.; Mpina M.; Nwando M.; Owusu M.; Wiley M.R.; Youtchou M.T.; Ayekaba M.O.; Abouelhoda M.; Seadawy M.G.; Khalifa M.K.; Sekhele M.; Ouadghiri M.; Diagne M.M.; Mwenda M.; Allam M.; Phan M.V.T.; Abid N.; Touil N.; Rujeni N.; Kharrat N.; Ismael N.; Dia N.; Mabunda N.; Hsiao N.-Y.; Silochi N.B.; Nsenga N.; Gumede N.; Mulder N.; Ndodo N.; Razanajatovo N.H.; Iguosadolo N.; Judith O.; Kingsley O.C.; Sylvanus O.; Peter O.; Femi O.; Idowu O.; Testimony O.; Chukwuma O.E.; Ogah O.E.; Onwuamah C.K.; Cyril O.; Faye O.; Tomori O.; Ondoa P.; Combe P.; Semanda P.; Oluniyi P.E.; Arnaldo P.; Quashie P.K.; Dussart P.; Bester P.A.; Mbala P.K.; Ayivor-Djanie R.; Njouom R.; Phillips R.O.; Gorman R.; Kingsley R.A.; Carr R.A.A.; El Kabbaj S.; Gargouri S.; Masmoudi S.; Sankhe S.; Lawal S.B.; Kassim S.; Trabelsi S.; Metha S.; Kammoun S.; Lemriss S.; Agwa S.H.A.; Calvignac-Spencer S.; Schaffner S.F.; Doumbia S.; Mandanda S.M.; Aryeetey S.; Ahmed S.S.; Elhamoumi S.; Andriamandimby S.; Tope S.; Lekana-Douki S.; Prosolek S.; Ouangraoua S.; Mundeke S.A.; Rudder S.; Panji S.; Pillay S.; Engelbrecht S.; Nabadda S.; Behillil S.; Budiaki S.L.; van der Werf S.; Mashe T.; Aanniz T.; Mohale T.; Le-Viet T.; Schindler T.; Anyaneji U.J.; Chinedu U.; Ramphal U.; Jessica U.; George U.; Fonseca V.; Enouf V.; Gorova V.; Roshdy W.H.; Ampofo W.K.; Preiser W.; Choga W.T.; Bediako Y.; Naidoo Y.; Butera Y.; de Laurent Z.R.; Sall A.A.; Rebai A.; von Gottberg A.; Kouriba B.; Williamson C.; Bridges D.J.; Chikwe I.; Bhiman J.N.; Mine M.; Cotten M.; Moyo S.; Gaseitsiwe S.; Saasa N.; Sabeti P.C.; Kaleebu P.; Tebeje Y.K.; Tessema S.K.; Happi C.; Nkengasong J.; de Oliveira T.
发表日期	2021
ISSN	0036-8075
起始页码	423
结束页码	431
卷号	374 期号:6566
英文摘要	The progression of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in Africa has so far been heterogeneous, and the full impact is not yet well understood. In this study, we describe the genomic epidemiology using a dataset of 8746 genomes from 33 African countries and two overseas territories. We show that the epidemics in most countries were initiated by importations predominantly from Europe, which diminished after the early introduction of international travel restrictions. As the pandemic progressed, ongoing transmission in many countries and increasing mobility led to the emergence and spread within the continent of many variants of concern and interest, such as B.1.351, B.1.525, A.23.1, and C.1.1. Although distorted by low sampling numbers and blind spots, the findings highlight that Africa must not be left behind in the global pandemic response, otherwise it could become a source for new variants. © 2021 American Association for the Advancement of Science. All rights reserved.
英文关键词	disease transmission; epidemiology; genomics; Africa; Article; cell lineage; controlled study; coronavirus disease 2019; epidemic; genetic epidemiology; genetic variability; genome; genome analysis; human; information processing; nonhuman; pandemic; Severe acute respiratory syndrome coronavirus 2; travel restriction; virus transmission; Africa; SARS coronavirus
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/246034
作者单位	KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa; Centre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch, South Africa; Laboratorio de Flavivirus, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil; Laboratório de Genética Celular e Molecular, Universidade Federal de Minas Gerais, Minas Gerais, Belo Horizonte, Brazil; Department of Geography and GIS, University of Cincinnati, Cincinnati, OH, United States; Institute of Infectious Diseases and Molecular Medicine, Department of Integrative Biomedical Sciences, Computational Biology Division, University of Cape Town, Cape Town, South Africa; Division of Medical Virology, Wellcome Centre for Infectious Diseases in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa; Department of Entomology and Plant Pathology, North...
推荐引用方式 GB/T 7714	Wilkinson E.,Giovanetti M.,Tegally H.,et al. A year of genomic surveillance reveals how the SARS-CoV-2 pandemic unfolded in Africa[J],2021,374(6566).
APA	Wilkinson E..,Giovanetti M..,Tegally H..,San J.E..,Lessells R..,...&de Oliveira T..(2021).A year of genomic surveillance reveals how the SARS-CoV-2 pandemic unfolded in Africa.Science,374(6566).
MLA	Wilkinson E.,et al."A year of genomic surveillance reveals how the SARS-CoV-2 pandemic unfolded in Africa".Science 374.6566(2021).