气候变化领域集成服务门户(CCPortal): Genomic history of the seventh pandemic of cholera in Africa

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DOI	10.1126/science.aad5901
	Genomic history of the seventh pandemic of cholera in Africa
	Weill F.-X.; Domman D.; Njamkepo E.; Tarr C.; Rauzier J.; Fawal N.; Keddy K.H.; Salje H.; Moore S.; Mukhopadhyay A.K.; Bercion R.; Luquero F.J.; Ngandjio A.; Dosso M.; Monakhova E.; Garin B.; Bouchier C.; Pazzani C.; Mutreja A.; Grunow R.; Sidikou F.; Bonte L.; Breurec S.; Damian M.; Njanpop-Lafourcade B.-M.; Sapriel G.; Page A.-L.; Hamze M.; Henkens M.; Chowdhury G.; Mengel M.; Koeck J.-L.; Fournier J.-M.; Dougan G.; Grimont P.A.D.; Parkhill J.; Holt K.E.; Piarroux R.; Ramamurthy T.; Quilici M.-L.; Thomson N.R.
发表日期	2017
ISSN	0036-8075
起始页码	785
结束页码	789
卷号	358 期号:6364
英文摘要	The seventh cholera pandemic has heavily affected Africa, although the origin and continental spread of the disease remain undefined. We used genomic data from 1070 Vibrio cholerae O1 isolates, across 45 African countries and over a 49-year period, to show that past epidemics were attributable to a single expanded lineage. This lineage was introduced at least 11 times since 1970, into two main regions, West Africa and East/Southern Africa, causing epidemics that lasted up to 28 years. The last five introductions into Africa, all from Asia, involved multidrug-resistant sublineages that replaced antibiotic-susceptible sublineages after 2000. This phylogenetic framework describes the periodicity of lineage introduction and the stable routes of cholera spread, which should inform the rational design of control measures for cholera in Africa. © 2017, American Association for the Advancement of Science. All rights reserved.
英文关键词	antibiotics; cholera; drug resistance; epidemic; genomics; periodicity; phylogenetics; Africa; antibiotic sensitivity; Article; bacterial genetics; bacterial genome; bacterium isolate; cholera; human; nonhuman; pandemic; periodicity; phylogeny; priority journal; single nucleotide polymorphism; Vibrio cholerae O1; Asia; cholera; classification; genetics; genomics; isolation and purification; microbiology; Asia; Southern Africa; West Africa; Vibrio cholerae; Africa, Eastern; Africa, Southern; Africa, Western; Asia; Cholera; Genome, Bacterial; Genomics; Humans; Pandemics; Phylogeny; Vibrio cholerae O1
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/245996
作者单位	Institut Pasteur, Unité des Bactéries Pathogènes Entériques, Paris, 75015, France; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, United Kingdom; Centers for Disease Control and Prevention, Escherichia and Shigella Reference Unit, Atlanta, GA 30333, United States; Centre for Enteric Diseases, National Institute for Communicable Diseases, Johannesburg, 2131, South Africa; Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 2193, South Africa; Institut Pasteur, Mathematical Modelling of Infectious Diseases, Paris, 75015, France; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, United States; Laboratoire de Parasitologie-Mycologie, CHU Timone, Université de la Méditerranée, Marseille, 13385, France; National Institute of Cholera and Enteric Diseases (NICED), Kolkata, West Bengal 700010, India; Institut Pasteur de Bangui, BP 923, Bangui, Central African Republic; Institut Pasteur de Dakar, BP 220, Dakar, Senegal; Epicentre, Pari...
推荐引用方式 GB/T 7714	Weill F.-X.,Domman D.,Njamkepo E.,et al. Genomic history of the seventh pandemic of cholera in Africa[J],2017,358(6364).
APA	Weill F.-X..,Domman D..,Njamkepo E..,Tarr C..,Rauzier J..,...&Thomson N.R..(2017).Genomic history of the seventh pandemic of cholera in Africa.Science,358(6364).
MLA	Weill F.-X.,et al."Genomic history of the seventh pandemic of cholera in Africa".Science 358.6364(2017).