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DOI	10.1126/science.aao4806
	Shifts in disease dynamics in a tropical amphibian assemblage are not due to pathogen attenuation
	Voyles J.; Woodhams D.C.; Saenz V.; Byrne A.Q.; Perez R.; Rios-Sotelo G.; Ryan M.J.; Bletz M.C.; Sobell F.A.; McLetchie S.; Reinert L.; Rosenblum E.B.; Rollins-Smith L.A.; Ibáñez R.; Ray J.M.; Griffith E.J.; Ross H.; Richards-Zawacki C.L.
发表日期	2018
ISSN	0036-8075
起始页码	1517
结束页码	1519
卷号	359 期号:6383
英文摘要	Infectious diseases rarely end in extinction.Yet the mechanisms that explain how epidemics subside are difficult to pinpoint.We investigated host-pathogen interactions after the emergence of a lethal fungal pathogen in a tropical amphibian assemblage. Some amphibian host species are recovering, but the pathogen is still present and is as pathogenic today as itwas almost a decade ago. In addition, some species have defenses that aremore effective now than they were before the epidemic.These results suggest that host recoveries are not caused by pathogen attenuation and may be due to shifts in host responses. Our findings provide insights into the mechanisms underlying disease transitions, which are increasingly important to understand in an era of emerging infectious diseases and unprecedented global pandemics. © The Authors, some rights reserved;.
英文关键词	amphibian; community composition; epidemic; extinction; fungal disease; host-pathogen interaction; infectious disease; pathogen; Amphibia; Article; copy number variation; disease transmission; genetic variability; host pathogen interaction; host resistance; immune evasion; immune reconstitution; immune response; mortality rate; nonhuman; pandemic; priority journal; seasonal variation; survival analysis; virulence; animal; animal disease; Anura; biological model; Chytridiomycetes; communicable disease; epidemic; microbiology; Panama; pathogenicity; Amphibia; Animal Diseases; Animals; Anura; Chytridiomycota; Communicable Diseases; Disease Outbreaks; Host-Pathogen Interactions; Models, Biological; Panama
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/245926
作者单位	Department of Biology, University of Nevada, Reno, Reno, NV, United States; Department of Biology, University of Massachusetts-Boston, Boston, MA, United States; Smithsonian Tropical Research Institute, Ancón, Panama; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, United States; Department of Environmental Science, Policy, and Management, University of California, Berkeley, Berkeley, CA, United States; Department of Biology, New Mexico Institute of Mining and Technology, Socorro, NM, United States; Arizona Game and Fish Department, Phoenix, AZ, United States; Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN, United States; Sistema Nacional de Investigación, Panamá, Panama; La Mica Biological Station, El Copé, Panama; Fundación Centro de Conservación de Anfibios, El Valle, Panama
推荐引用方式 GB/T 7714	Voyles J.,Woodhams D.C.,Saenz V.,et al. Shifts in disease dynamics in a tropical amphibian assemblage are not due to pathogen attenuation[J],2018,359(6383).
APA	Voyles J..,Woodhams D.C..,Saenz V..,Byrne A.Q..,Perez R..,...&Richards-Zawacki C.L..(2018).Shifts in disease dynamics in a tropical amphibian assemblage are not due to pathogen attenuation.Science,359(6383).
MLA	Voyles J.,et al."Shifts in disease dynamics in a tropical amphibian assemblage are not due to pathogen attenuation".Science 359.6383(2018).