气候变化领域集成服务门户(CCPortal): The exposome and health: Where chemistry meets biology

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DOI	10.1126/science.aay3164
	The exposome and health: Where chemistry meets biology
	Vermeulen R.; Schymanski E.L.; Barabási A.-L.; Miller G.W.
发表日期	2020
ISSN	0036-8075
起始页码	392
结束页码	396
卷号	367 期号:6476
英文摘要	Despite extensive evidence showing that exposure to specific chemicals can lead to disease, current research approaches and regulatory policies fail to address the chemical complexity of our world. To safeguard current and future generations from the increasing number of chemicals polluting our environment, a systematic and agnostic approach is needed. The “exposome” concept strives to capture the diversity and range of exposures to synthetic chemicals, dietary constituents, psychosocial stressors, and physical factors, as well as their corresponding biological responses. Technological advances such as high-resolution mass spectrometry and network science have allowed us to take the first steps toward a comprehensive assessment of the exposome. Given the increased recognition of the dominant role that nongenetic factors play in disease, an effort to characterize the exposome at a scale comparable to that of the human genome is warranted. © 2020 American Association for the Advancement of Science. All rights reserved.
英文关键词	chemical composition; dietary intake; genome; pollution incidence; psychology; public health; air pollution; Article; biology; chemistry; exposome; gene; health; human; priority journal; soil pollution; water pollution; adverse event; complication; dietary supplement; diseases; genetics; human genome; mental stress; physical phenomena; risk assessment; organic compound; Dietary Supplements; Disease; Exposome; Genome, Human; Health; Humans; Organic Chemicals; Physical Phenomena; Risk Assessment; Stress, Psychological
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/245847
作者单位	Institute for Risk Assessment Sciences, Division of Environmental Epidemiology, Utrecht University, Utrecht, Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg; Network Science Institute, Northeastern University, Boston, MA, United States; Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States; Department of Network and Data Science, Central European University, Budapest, Hungary; Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, United States
推荐引用方式 GB/T 7714	Vermeulen R.,Schymanski E.L.,Barabási A.-L.,et al. The exposome and health: Where chemistry meets biology[J],2020,367(6476).
APA	Vermeulen R.,Schymanski E.L.,Barabási A.-L.,&Miller G.W..(2020).The exposome and health: Where chemistry meets biology.Science,367(6476).
MLA	Vermeulen R.,et al."The exposome and health: Where chemistry meets biology".Science 367.6476(2020).