气候变化领域集成服务门户(CCPortal): A genome-wide transcriptomic analysis of protein-coding genes in human blood cells

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DOI	10.1126/science.aax9198
	A genome-wide transcriptomic analysis of protein-coding genes in human blood cells
	Uhlen M.; Karlsson M.J.; Zhong W.; Tebani A.; Pou C.; Mikes J.; Lakshmikanth T.; Forsström B.; Edfors F.; Odeberg J.; Mardinoglu A.; Zhang C.; von Feilitzen K.; Mulder J.; Sjöstedt E.; Hober A.; Oksvold P.; Zwahlen M.; Ponten F.; Lindskog C.; Sivertsson Å.; Fagerberg L.; Brodin P.
发表日期	2019
ISSN	0036-8075
卷号	366 期号:6472
英文摘要	Blood is the predominant source for molecular analyses in humans, both in clinical and research settings. It is the target for many therapeutic strategies, emphasizing the need for comprehensive molecular maps of the cells constituting human blood. In this study, we performed a genome-wide transcriptomic analysis of protein-coding genes in sorted blood immune cell populations to characterize the expression levels of each individual gene across the blood cell types. All data are presented in an interactive, open-access Blood Atlas as part of the Human Protein Atlas and are integrated with expression profiles across all major tissues to provide spatial classification of all protein-coding genes. This allows for a genome-wide exploration of the expression profiles across human immune cell populations and all major human tissues and organs. Copyright © 2019 The Authors.
英文关键词	cell; gene; gene expression; genetic analysis; genome; immune response; molecular analysis; protein; article; cell population; gene expression; human; human cell; immunocompetent cell; blood cell; gene expression profiling; genetics; genome-wide association study; metabolism; protein; transcriptome; Blood Cells; Gene Expression Profiling; Genome-Wide Association Study; Humans; Proteins; Transcriptome
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/245799
作者单位	Science for Life Laboratory, KTH–Royal Institute of Technology, Stockholm, Sweden; Department of Neuroscience, Karolinska Institute, Stockholm, Sweden; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark; Science for Life Laboratory, Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden; Coagulation Unit, Department of Hematology, Karolinska University Hospital, Stockholm, Sweden; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King’s College London, London, United Kingdom; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden; Unit of Pediatric Rheumatology, Karolinska University Hospital, Stockholm, Sweden
推荐引用方式 GB/T 7714	Uhlen M.,Karlsson M.J.,Zhong W.,et al. A genome-wide transcriptomic analysis of protein-coding genes in human blood cells[J],2019,366(6472).
APA	Uhlen M..,Karlsson M.J..,Zhong W..,Tebani A..,Pou C..,...&Brodin P..(2019).A genome-wide transcriptomic analysis of protein-coding genes in human blood cells.Science,366(6472).
MLA	Uhlen M.,et al."A genome-wide transcriptomic analysis of protein-coding genes in human blood cells".Science 366.6472(2019).