气候变化领域集成服务门户(CCPortal): Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention

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DOI	10.1126/science.aaf9011
	Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention
	Tomasetti C.; Li L.; Vogelstein B.
发表日期	2017
ISSN	0036-8075
起始页码	1330
结束页码	1334
卷号	355 期号:6331
英文摘要	Cancers are caused by mutations that may be inherited, induced by environmental factors, or result from DNA replication errors (R).We studied the relationship between the number of normal stem cell divisions and the risk of 17 cancer types in 69 countries throughout the world. The data revealed a strong correlation (median = 0.80) between cancer incidence and normal stem cell divisions in all countries, regardless of their environment. The major role of R mutations in cancer etiology was supported by an independent approach, based solely on cancer genome sequencing and epidemiological data, which suggested that R mutations are responsible for two-thirds of the mutations in human cancers. All of these results are consistent with epidemiological estimates of the fraction of cancers that can be prevented by changes in the environment. Moreover, they accentuate the importance of early detection and intervention to reduce deaths from the many cancers arising from unavoidable R mutations.
英文关键词	cancer; cells and cell components; disease treatment; epidemiology; etiology; genomics; mutation; adolescent; adult; aged; Article; breast cancer; cancer classification; cancer epidemiology; cancer incidence; cancer patient; cancer prevention; cancer registry; cancer risk; cell division; child; controlled study; correlation coefficient; DNA replication; early cancer diagnosis; environmental factor; female; human; human cell; human tissue; lung adenocarcinoma; major clinical study; male; malignant neoplasm; multicenter study; pancreas adenocarcinoma; priority journal; prostate adenocarcinoma; risk factor; somatic mutation; stem cell; very elderly; Africa; Asia; Caribbean; cytology; genetics; genotype environment interaction; incidence; mutation; Neoplasms; North America; Pacific islands; primary prevention; South and Central America; stem cell; Africa; Asia; Caribbean Region; Cell Division; DNA Replication; Female; Gene-Environment Interaction; Humans; Incidence; Latin America; Male; Mutation; Neoplasms; North America; Oceania; Primary Prevention; Stem Cells
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/245762
作者单位	Division of Biostatistics and Bioinformatics, Department of Oncology, Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, 550 North Broadway, Baltimore, MD 21205, United States; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, United States; Ludwig Center and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, 1650 Orleans Street, Baltimore, MD 21205, United States
推荐引用方式 GB/T 7714	Tomasetti C.,Li L.,Vogelstein B.. Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention[J],2017,355(6331).
APA	Tomasetti C.,Li L.,&Vogelstein B..(2017).Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention.Science,355(6331).
MLA	Tomasetti C.,et al."Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention".Science 355.6331(2017).