气候变化领域集成服务门户(CCPortal): mRNA vaccination boosts cross-variant neutralizing antibodies elicited by SARS-CoV-2 infection

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DOI	10.1126/science.abg9175
	mRNA vaccination boosts cross-variant neutralizing antibodies elicited by SARS-CoV-2 infection
	Stamatatos L.; Czartoski J.; Wan Y.-H.; Homad L.J.; Rubin V.; Glantz H.; Neradilek M.; Seydoux E.; Jennewein M.F.; MacCamy A.J.; Feng J.; Mize G.; De Rosa S.C.; Finzi A.; Lemos M.P.; Cohen K.W.; Moodie Z.; McElrath M.J.; McGuire A.T.
发表日期	2021
ISSN	0036-8075
起始页码	1413
结束页码	1418
卷号	372 期号:6549
英文摘要	Emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have raised concerns about resistance to neutralizing antibodies elicited by previous infection or vaccination. We examined whether sera from recovered and naïve donors, collected before and after immunizations with existing messenger RNA (mRNA) vaccines, could neutralize the Wuhan-Hu-1 and B.1.351 variants. Prevaccination sera from recovered donors neutralized Wuhan-Hu-1 and sporadically neutralized B.1.351, but a single immunization boosted neutralizing titers against all variants and SARS-CoV-1 by up to 1000-fold. Neutralization was a result of antibodies targeting the receptor binding domain and was not boosted by a second immunization. Immunization of naïve donors also elicited cross-neutralizing responses but at lower titers. Our study highlights the importance of vaccinating both uninfected and previously infected persons to elicit cross-variant neutralizing antibodies. © 2021 American Association for the Advancement of Science. All rights reserved.
英文关键词	SARS coronavirus
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/245590
作者单位	Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States; Department of Global Health, University of Washington, Seattle, WA, United States; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, United States; Centre de Recherche du CHUM, Montréal, QC, Canada; Département de Microbiologie Infectiologie et Immunologie, Université de Montréal, Montreal, QC, Canada; Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada; Department of Medicine, University of Washington, Seattle, WA, United States
推荐引用方式 GB/T 7714	Stamatatos L.,Czartoski J.,Wan Y.-H.,et al. mRNA vaccination boosts cross-variant neutralizing antibodies elicited by SARS-CoV-2 infection[J],2021,372(6549).
APA	Stamatatos L..,Czartoski J..,Wan Y.-H..,Homad L.J..,Rubin V..,...&McGuire A.T..(2021).mRNA vaccination boosts cross-variant neutralizing antibodies elicited by SARS-CoV-2 infection.Science,372(6549).
MLA	Stamatatos L.,et al."mRNA vaccination boosts cross-variant neutralizing antibodies elicited by SARS-CoV-2 infection".Science 372.6549(2021).