气候变化领域集成服务门户(CCPortal): Molecular and cellular reorganization of neural circuits in the human lineage

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DOI	10.1126/science.aan3456
	Molecular and cellular reorganization of neural circuits in the human lineage
	Sousa A.M.M.; Zhu Y.; Raghanti M.A.; Kitchen R.R.; Onorati M.; Tebbenkamp A.T.N.; Stutz B.; Meyer K.A.; Li M.; Kawasawa Y.I.; Liu F.; Perez R.G.; Mele M.; Carvalho T.; Skarica M.; Gulden F.O.; Pletikos M.; Shibata A.; Stephenson A.R.; Edler M.K.; Ely J.J.; Elsworth J.D.; Horvath T.L.; Hof P.R.; Hyde T.M.; Kleinman J.E.; Weinberger D.R.; Reimers M.; Lifton R.P.; Mane S.M.; Noonan J.P.; State M.W.; Lein E.S.; Knowles J.A.; Marques-Bonet T.; Sherwood C.C.; Gerstein M.B.; Sestan N.
发表日期	2017
ISSN	0036-8075
起始页码	1027
结束页码	1032
卷号	358 期号:6366
英文摘要	To better understand the molecular and cellular differences in brain organization between human and nonhuman primates, we performed transcriptome sequencing of 16 regions of adult human, chimpanzee, and macaque brains. Integration with human single-cell transcriptomic data revealed global, regional, and cell-type–specific species expression differences in genes representing distinct functional categories. We validated and further characterized the human specificity of genes enriched in distinct cell types through histological and functional analyses, including rare subpallial-derived interneurons expressing dopamine biosynthesis genes enriched in the human striatum and absent in the nonhuman African ape neocortex. Our integrated analysis of the generated data revealed diverse molecular and cellular features of the phylogenetic reorganization of the human brain across multiple levels, with relevance for brain function and disease. © 2017, American Association for the Advancement of Science. All rights reserved.
英文关键词	ADORA2A protein; aromatic levo amino acid decarboxylase; C1QL2 protein; CPXM2 protein; dopamine; dopamine 1 receptor; dopamine 2 receptor; dopamine 3 receptor; dopamine beta monooxygenase; glutamate decarboxylase; glutamate decarboxylase 1; glutamate decarboxylase 2; messenger RNA; microRNA; myelin basic protein; neurotransmitter receptor; noradrenalin; PARM1 protein; peptides and proteins; PKD2L1 protein; scatter factor receptor; somatostatin; transcription factor; transcription factor ER81; transcription factor ETV5; transcriptome; transient receptor potential channel M3; Twist related protein 1; tyrosine 3 monooxygenase; unclassified drug; ZP2 protein; transcriptome; brain; cells and cell components; genetic analysis; human evolution; molecular analysis; nervous system; phylogenetics; primate; adult; amygdala; animal tissue; Article; astrocyte; brain development; brain function; cell lineage; cell specificity; cellular, subcellular and molecular biological phenomena and functions; cerebellum cortex; controlled study; corpus striatum; dopamine metabolism; dopaminergic nerve cell; dopaminergic system; GABAergic system; gene expression; gene expression profiling; hippocampus; human; human cell; human tissue; immunohistochemistry; interneuron; microglia; molecular phylogeny; neocortex; nerve cell; nerve cell differentiation; newborn; nonhuman; oligodendroglia; priority journal; pyramidal nerve cell; single cell analysis; species difference; transcriptomics; animal; comparative study; genetics; growth, development and aging; Macaca; metabolism; nerve tract; Pan troglodytes; phylogeny; Pan; Primates; Animals; Gene Expression Profiling; Humans; Interneurons; Macaca; Neocortex; Neural Pathways; Pan troglodytes; Phylogeny; Species Specificity; Transcriptome
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/245565
作者单位	Department of Neuroscience, Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT, United States; Department of Anthropology, School of Biomedical Sciences, Kent State University, Kent, OH, United States; Program in Computational Biology and Bioinformatics, Departments of Molecular Biophysics and Biochemistry and Computer Science, Yale University, New Haven, CT, United States; Department of Psychiatry, Yale School of Medicine, New Haven, CT, United States; Department of Biology, Unit of Cell and Developmental Biology, University of Pisa, Pisa, Italy; Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, New Haven, CT, United States; Departments of Pharmacology and Biochemistry and Molecular Biology, Institute for Personalized Medicine, Pennsylvania State University College of Medicine, Hershey, PA, United States; Institut de Biologia Evolutiva, Consejo Superior de Investigaciones Científicas, Universitat Pompeu Fabra, Barcelona Biomedi...
推荐引用方式 GB/T 7714	Sousa A.M.M.,Zhu Y.,Raghanti M.A.,et al. Molecular and cellular reorganization of neural circuits in the human lineage[J],2017,358(6366).
APA	Sousa A.M.M..,Zhu Y..,Raghanti M.A..,Kitchen R.R..,Onorati M..,...&Sestan N..(2017).Molecular and cellular reorganization of neural circuits in the human lineage.Science,358(6366).
MLA	Sousa A.M.M.,et al."Molecular and cellular reorganization of neural circuits in the human lineage".Science 358.6366(2017).