气候变化领域集成服务门户(CCPortal): Sharing vitamins: Cobamides unveil microbial interactions

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DOI	10.1126/science.aba0165
	Sharing vitamins: Cobamides unveil microbial interactions
	Sokolovskaya O.M.; Shelton A.N.; Taga M.E.
发表日期	2020
ISSN	0036-8075
卷号	369 期号:6499
英文摘要	Microbial communities are essential to fundamental processes on Earth. Underlying the compositions and functions of these communities are nutritional interdependencies among individual species. One class of nutrients, cobamides (the family of enzyme cofactors that includes vitamin B12), is widely used for a variety of microbial metabolic functions, but these structurally diverse cofactors are synthesized by only a subset of bacteria and archaea. Advances at different scales of study-from individual isolates, to synthetic consortia, to complex communities-have led to an improved understanding of cobamide sharing. Here, we discuss how cobamides affect microbes at each of these three scales and how integrating different approaches leads to a more complete understanding of microbial interactions. © 2020 American Association for the Advancement of Science. All rights reserved.
英文关键词	cobamamide; messenger RNA; methylmalonyl coenzyme A mutase; propionic acid; cobamamide; vitamin B complex; bacterium; enzyme; enzyme activity; microbial activity; microbial community; vitamin; 5' untranslated region; Akkermansia muciniphila; amino acid metabolism; Anaerostipes caccae; Article; bacterium culture; bacterium isolate; Bacteroides thetaiotaomicron; binding affinity; Caenorhabditis elegans; carbon source; Caulobacter vibrioides; chemical structure; Chlamydomonadales; Clostridioides difficile; Dehalococcoides mccartyi; down regulation; enzyme activity; Escherichia coli; Eubacterium hallii; Faecalibacterium prausnitzii; gene expression; human; in vitro study; intestine flora; Lachnospiraceae; Lobomonas rostrata; Mesorhizobium; Mesorhizobium loti; microbial community; microbial growth; microbial interaction; microbial metabolism; nonhuman; phenotype; prediction; priority journal; Propionibacterium acnes; protein folding; riboswitch; Sinorhizobium meliloti; Sporomusa; Sporomusa ovata; synthesis; Vibrio cholerae; animal; archaeon; bacterium; biological model; chemistry; environment; eukaryote; metabolism; microflora; organismal interaction; Animals; Archaea; Bacteria; Cobamides; Earth, Planet; Environment; Eukaryota; Microbial Interactions; Microbiota; Models, Biological; Vitamin B Complex
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/245548
作者单位	Department of Plant and Microbial Biology, University of California, Berkeley, CA, United States
推荐引用方式 GB/T 7714	Sokolovskaya O.M.,Shelton A.N.,Taga M.E.. Sharing vitamins: Cobamides unveil microbial interactions[J],2020,369(6499).
APA	Sokolovskaya O.M.,Shelton A.N.,&Taga M.E..(2020).Sharing vitamins: Cobamides unveil microbial interactions.Science,369(6499).
MLA	Sokolovskaya O.M.,et al."Sharing vitamins: Cobamides unveil microbial interactions".Science 369.6499(2020).