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DOI	10.1126/science.aat7244
	Convergent regulatory evolution and loss of flight in paleognathous birds
	Sackton T.B.; Grayson P.; Cloutier A.; Hu Z.; Liu J.S.; Wheeler N.E.; Gardner P.P.; Clarke J.A.; Baker A.J.; Clamp M.; Edwards S.V.
发表日期	2019
ISSN	0036-8075
起始页码	74
结束页码	78
卷号	364 期号:6435
英文摘要	A core question in evolutionary biology is whether convergent phenotypic evolution is driven by convergent molecular changes in proteins or regulatory regions. We combined phylogenomic, developmental, and epigenomic analysis of 11 new genomes of paleognathous birds, including an extinct moa, to show that convergent evolution of regulatory regions, more so than protein-coding genes, is prevalent among developmental pathways associated with independent losses of flight. A Bayesian analysis of 284,001 conserved noncoding elements, 60,665 of which are corroborated as enhancers by open chromatin states during development, identified 2355 independent accelerations along lineages of flightless paleognaths, with functional consequences for driving gene expression in the developing forelimb. Our results suggest that the genomic landscape associated with morphological convergence in ratites has a substantial shared regulatory component. 2017 © The Authors.
英文关键词	Bayesian analysis; bird; convergent evolution; developmental biology; evolutionary biology; gene; gene expression; genomics; morphology; phenotype; protein; acceleration; article; Bayes theorem; chromatin; convergent evolution; enhancer region; epigenetics; forelimb; gene expression; landscape; nonhuman; ratite; anatomy and histology; animal; conserved sequence; evolution; exon; flying; genetic epigenesis; genetics; metabolism; molecular evolution; phenotype; phylogeny; physiology; ratite; species extinction; Aves; Animals; Bayes Theorem; Biological Evolution; Chromatin; Conserved Sequence; Enhancer Elements, Genetic; Epigenesis, Genetic; Epigenomics; Evolution, Molecular; Exons; Extinction, Biological; Flight, Animal; Forelimb; Palaeognathae; Phenotype; Phylogeny
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/245316
作者单位	Informatics Group, Harvard University, Cambridge, MA, United States; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, United States; Museum of Comparative Zoology, Harvard University, Cambridge, MA, United States; Department of Statistics, Harvard University, Cambridge, MA, United States; School of Biological Sciences, University of Canterbury, Christchurch, New Zealand; Centre for Genomic Pathogen Surveillance, Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, United Kingdom; Department of Biochemistry, University of Otago, Dunedin, New Zealand; Jackson School of Geosciences, University of Texas, Austin, TX, United States; Department of Natural History, Royal Ontario Museum, Toronto, ON, Canada; Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, Canada
推荐引用方式 GB/T 7714	Sackton T.B.,Grayson P.,Cloutier A.,et al. Convergent regulatory evolution and loss of flight in paleognathous birds[J],2019,364(6435).
APA	Sackton T.B..,Grayson P..,Cloutier A..,Hu Z..,Liu J.S..,...&Edwards S.V..(2019).Convergent regulatory evolution and loss of flight in paleognathous birds.Science,364(6435).
MLA	Sackton T.B.,et al."Convergent regulatory evolution and loss of flight in paleognathous birds".Science 364.6435(2019).