气候变化领域集成服务门户(CCPortal): A tensile ring drives tissue flows to shape the gastrulating amniote embryo

CCPortal

DOI	10.1126/science.aaw1965
	A tensile ring drives tissue flows to shape the gastrulating amniote embryo
	Saadaoui M.; Rocancourt D.; Roussel J.; Corson F.; Gros J.
发表日期	2020
ISSN	0036-8075
起始页码	453
结束页码	458
卷号	367 期号:6476
英文摘要	Tissue morphogenesis is driven by local cellular deformations that are powered by contractile actomyosin networks. How localized forces are transmitted across tissues to shape them at a mesoscopic scale is still unclear. Analyzing gastrulation in entire avian embryos, we show that it is driven by the graded contraction of a large-scale supracellular actomyosin ring at the margin between the embryonic and extraembryonic territories. The propagation of these forces is enabled by a fluid-like response of the epithelial embryonic disk, which depends on cell division. A simple model of fluid motion entrained by a tensile ring quantitatively captures the vortex-like “polonaise” movements that accompany the formation of the primitive streak. The geometry of the early embryo thus arises from the transmission of active forces generated along its boundary. Copyright © 2020 The Authors,
英文关键词	cell; embryonic development; fluid flow; geometry; morphogenesis; article; bird; cell division; embryo; gastrulation; geometry; motion; nonhuman; primitive streak; amnion; animal; anisotropy; chemistry; embryology; nonmammalian embryo; physiology; quail; tensile strength; Aves; myosin adenosine triphosphatase; Actomyosin; Amnion; Animals; Anisotropy; Cell Division; Embryo, Nonmammalian; Gastrulation; Quail; Tensile Strength
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/245309
作者单位	Department of Developmental and Stem Cell Biology Institut Pasteur, Paris, Cedex 15, 75724, France; CNRS UMR3738, Paris, 75015, France; Laboratoire de Physique de l'Ecole Normale Supérieure, CNRS, ENS, Université PSL, Sorbonne Université, Université de Paris, Paris, 75005, France; Institut du Cerveau et de la Moelle Épinière, Paris, France
推荐引用方式 GB/T 7714	Saadaoui M.,Rocancourt D.,Roussel J.,et al. A tensile ring drives tissue flows to shape the gastrulating amniote embryo[J],2020,367(6476).
APA	Saadaoui M.,Rocancourt D.,Roussel J.,Corson F.,&Gros J..(2020).A tensile ring drives tissue flows to shape the gastrulating amniote embryo.Science,367(6476).
MLA	Saadaoui M.,et al."A tensile ring drives tissue flows to shape the gastrulating amniote embryo".Science 367.6476(2020).