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| DOI | 10.1126/science.aax1184 |
| Obesity remodels activity and transcriptional state of a lateral hypothalamic brake on feeding | |
| Rossi M.A.; Basiri M.L.; McHenry J.A.; Kosyk O.; Otis J.M.; Van Den Munkhof H.E.; Bryois J.; Hübel C.; Breen G.; Guo W.; Bulik C.M.; Sullivan P.F.; Stuber G.D. | |
| 发表日期 | 2019 |
| ISSN | 0036-8075 |
| 起始页码 | 1271 |
| 结束页码 | 1274 |
| 卷号 | 364期号:6447 |
| 英文摘要 | The current obesity epidemic is a major worldwide health concern. Despite the consensus that the brain regulates energy homeostasis, the neural adaptations governing obesity are unknown. Using a combination of high-throughput single-cell RNA sequencing and longitudinal in vivo two-photon calcium imaging, we surveyed functional alterations of the lateral hypothalamic area (LHA) - a highly conserved brain region that orchestrates feeding - in a mouse model of obesity. The transcriptional profile of LHA glutamatergic neurons was affected by obesity, exhibiting changes indicative of altered neuronal activity. Encoding properties of individual LHA glutamatergic neurons were then tracked throughout obesity, revealing greatly attenuated reward responses.These data demonstrate how diet disrupts the function of an endogenous feeding suppression system to promote overeating and obesity. © 2019 American Association for the Advancement of Science. All rights reserved. |
| 英文关键词 | RNA; glutamic acid; Slc17a6 protein, mouse; transcriptome; vesicular glutamate transporter 2; brain; cell; epidemiology; genetic analysis; mutation; numerical model; obesity; animal cell; animal experiment; animal model; Article; controlled study; feeding; fluorescence in situ hybridization; gene expression; glutamatergic neuron; imaging; in vivo study; lateral hypothalamus; lipid diet; mouse; multiphoton microscopy; nerve cell; nonhuman; obesity; oligodendroglia; priority journal; reward; RNA sequence; animal; disease model; genetics; lateral hypothalamus; metabolism; obesity; pathophysiology; psychology; Animals; Diet, High-Fat; Disease Models, Animal; Glutamic Acid; Hypothalamic Area, Lateral; Mice; Neurons; Obesity; Reward; Transcriptome; Vesicular Glutamate Transport Protein 2 |
| 语种 | 英语 |
| 来源期刊 | Science
 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/245292 |
| 作者单位 | Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599, United States; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK, United Kingdom; UK National Institute for Health Research Biomedical Research Centre, South London and Maudsley Hospital, London, United Kingdom; Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, United States; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, United States; Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States; Department of Anesthesiology and Pain Medicine, Center for the Neurobiology of Addiction, Pain, and Emotion, University of Washing... |
| 推荐引用方式 GB/T 7714 | Rossi M.A.,Basiri M.L.,McHenry J.A.,et al. Obesity remodels activity and transcriptional state of a lateral hypothalamic brake on feeding[J],2019,364(6447). |
| APA | Rossi M.A..,Basiri M.L..,McHenry J.A..,Kosyk O..,Otis J.M..,...&Stuber G.D..(2019).Obesity remodels activity and transcriptional state of a lateral hypothalamic brake on feeding.Science,364(6447). |
| MLA | Rossi M.A.,et al."Obesity remodels activity and transcriptional state of a lateral hypothalamic brake on feeding".Science 364.6447(2019). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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