气候变化领域集成服务门户(CCPortal): Product-to-parent reversion of trenbolone: Unrecognized risks for endocrine disruption

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DOI	10.1126/science.1243192
	Product-to-parent reversion of trenbolone: Unrecognized risks for endocrine disruption
	Qu S.; Kolodziej E.P.; Long S.A.; Gloer J.B.; Patterson E.V.; Baltrusaitis J.; Jones G.D.; Benchetler P.V.; Cole E.A.; Kimbrough K.C.; Tarnoff M.D.; Cwiertny D.M.
发表日期	2013
ISSN	0036-8075
起始页码	347
结束页码	351
卷号	342 期号:6156
英文摘要	Trenbolone acetate (TBA) is a high-value steroidal growth promoter often administered to beef cattle, whose metabolites are potent endocrine-disrupting compounds. We performed laboratory and field phototransformation experiments to assess the fate of TBA metabolites and their photoproducts. Unexpectedly, we observed that the rapid photohydration of TBA metabolites is reversible under conditions representative of those in surface waters (pH 7, 25°C). This product-to-parent reversion mechanism results in diurnal cycling and substantial regeneration of TBA metabolites at rates that are strongly temperature- and pH-dependent. Photoproducts can also react to produce structural analogs of TBA metabolites. These reactions also occur in structurally similar steroids, including human pharmaceuticals, which suggests that predictive fate models and regulatory risk assessment paradigms must account for transformation products of high-risk environmental contaminants such as endocrine-disrupting steroids.
英文关键词	endocrine disruptor; trenbolone acetate; acetate; cattle; endocrine disruptor; metabolite; metapelite; regeneration; risk assessment; article; circadian rhythm; endocrine disease; hydroxylation; liquid chromatography; metabolite; nuclear magnetic resonance; pH; priority journal; risk assessment; seasonal variation; tandem mass spectrometry; temperature; Bos
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/245153
作者单位	Department of Civil and Environmental Engineering, University of Iowa, 4105 Seamans Center for the Engineering Arts and Sciences, Iowa City, IA 52242-1527, United States; Department of Civil and Environmental Engineering, University of Nevada, Reno, Mail Stop 258, Reno, NV 89557, United States; Department of Chemistry, University of Iowa, Iowa City, IA 52242-1527, United States; Department of Chemistry, Truman State University, Kirksville, MO 63501, United States; PhotoCatalytic Synthesis Group, MESA+ Institute for Nanotechnology, University of Twente, Meander 225, Post Office Box 217, 7500 AE Enschede, Netherlands; Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, IA 52242, United States; Department of Chemical and Biochemical Engineering, University of Iowa, 4133 Seamans Center for the Engineering Arts and Sciences, Iowa City, IA 52242-1527, United States
推荐引用方式 GB/T 7714	Qu S.,Kolodziej E.P.,Long S.A.,et al. Product-to-parent reversion of trenbolone: Unrecognized risks for endocrine disruption[J],2013,342(6156).
APA	Qu S..,Kolodziej E.P..,Long S.A..,Gloer J.B..,Patterson E.V..,...&Cwiertny D.M..(2013).Product-to-parent reversion of trenbolone: Unrecognized risks for endocrine disruption.Science,342(6156).
MLA	Qu S.,et al."Product-to-parent reversion of trenbolone: Unrecognized risks for endocrine disruption".Science 342.6156(2013).