气候变化领域集成服务门户(CCPortal): A transmissible cancer shifts from emergence to endemism in Tasmanian devils

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DOI	10.1126/science.abb9772
	A transmissible cancer shifts from emergence to endemism in Tasmanian devils
	Patton A.H.; Lawrance M.F.; Margres M.J.; Kozakiewicz C.P.; Hamede R.; Ruiz-Aravena M.; Hamilton D.G.; Comte S.; Ricci L.E.; Taylor R.L.; Stadler T.; Leaché A.; McCallum H.; Jones M.E.; Hohenlohe P.A.; Storfer A.
发表日期	2020
ISSN	0036-8075
卷号	370 期号:6522
英文摘要	Emerging infectious diseases pose one of the greatest threats to human health and biodiversity. Phylodynamics is often used to infer epidemiological parameters essential for guiding intervention strategies for human viruses such as severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2). Here, we applied phylodynamics to elucidate the epidemiological dynamics of Tasmanian devil facial tumor disease (DFTD), a fatal, transmissible cancer with a genome thousands of times larger than that of any virus. Despite prior predictions of devil extinction, transmission rates have declined precipitously from ∼3.5 secondary infections per infected individual to ∼1 at present. Thus, DFTD appears to be transitioning from emergence to endemism, lending hope for the continued survival of the endangered Tasmanian devil. More generally, our study demonstrates a new phylodynamic analytical framework that can be applied to virtually any pathogen. © 2020 American Association for the Advancement of Science. All rights reserved.
英文关键词	cancer; emergence; endemism; epidemiology; genome; infectious disease; severe acute respiratory syndrome; strategic approach; tumor; virus; analytic method; animal tissue; Article; controlled study; devil facial tumor disease; disease transmission; endangered species; endemic disease; gene identification; genetic screening; genome; nonhuman; phylodynamics; phylogeny; phylogeography; prediction; priority journal; secondary infection; single nucleotide polymorphism; species extinction; survival; tumor biopsy; whole genome sequencing; animal; communicable disease; endemic disease; face tumor; genetics; marsupial; Tasmania; veterinary medicine; Australia; Tasmania; Sarcophilus harrisii; SARS coronavirus; Animals; Communicable Diseases, Emerging; Endemic Diseases; Extinction, Biological; Facial Neoplasms; Marsupialia; Phylogeny; Tasmania
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/245011
作者单位	School of Biological Sciences, Washington State University, Pullman, WA 99164, United States; Department of Integrative Biology and Museum of Vertebrate Zoology, University of California, Berkeley, CA 94720, United States; Department of Integrative Biology, University of South Florida, Tampa, FL 33620, United States; School of Biological Sciences, University of Tasmania, Hobart, TAS 7001, Australia; CANECEV, Centre de Recherches Ecologiques et Evolutives sur le Cancer (CREEC), Montpellier, 34090, France; Department of Microbiology and Immunology, Montana State University, Bozeman, MT 59717, United States; Vertebrate Pest Research Unit, Invasive Species and Biosecurity, NSW Department of Primary Industries, Orange, NSW 2800, Australia; Department of Wildland Resources, Utah State University, Logan, UT 84322, United States; Department for Biosystems Science and Engineering, ETH Zürich, Basel, 4058, Switzerland; Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland; Department of Biology and ...
推荐引用方式 GB/T 7714	Patton A.H.,Lawrance M.F.,Margres M.J.,et al. A transmissible cancer shifts from emergence to endemism in Tasmanian devils[J],2020,370(6522).
APA	Patton A.H..,Lawrance M.F..,Margres M.J..,Kozakiewicz C.P..,Hamede R..,...&Storfer A..(2020).A transmissible cancer shifts from emergence to endemism in Tasmanian devils.Science,370(6522).
MLA	Patton A.H.,et al."A transmissible cancer shifts from emergence to endemism in Tasmanian devils".Science 370.6522(2020).