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DOI	10.1126/science.aap8809
	Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex
	Nowakowski T.J.; Bhaduri A.; Pollen A.A.; Alvarado B.; Mostajo-Radji M.A.; Di Lullo E.; Haeussler M.; Sandoval-Espinosa C.; Liu S.J.; Velmeshev D.; Ounadjela J.R.; Shuga J.; Wang X.; Lim D.A.; West J.A.; Leyrat A.A.; Kent W.J.; Kriegstein A.R.
发表日期	2017
ISSN	0036-8075
起始页码	1318
结束页码	1323
卷号	358 期号:6368
英文摘要	Systematic analyses of spatiotemporal gene expression trajectories during organogenesis have been challenging because diverse cell types at different stages of maturation and differentiation coexist in the emerging tissues. We identified discrete cell types as well as temporally and spatially restricted trajectories of radial glia maturation and neurogenesis in developing human telencephalon. These lineage-specific trajectories reveal the expression of neurogenic transcription factors in early radial glia and enriched activation of mammalian target of rapamycin signaling in outer radial glia. Across cortical areas, modest transcriptional differences among radial glia cascade into robust typological distinctions among maturing neurons. Together, our results support a mixed model of topographical, typological, and temporal hierarchies governing cell-type diversity in the developing human telencephalon, including distinct excitatory lineages emerging in rostral and caudal cerebral cortex. © 2017, American Association for the Advancement of Science. All rights reserved.
英文关键词	mammalian target of rapamycin; messenger RNA; transcription factor EMX1; transcription factor NFAT; cells and cell components; developmental biology; differentiation; gene; gene expression; maturation; nervous system; Article; brain cortex; brain development; cell lineage; cell maturation; gene expression; glia; human; mTOR signaling; nervous system development; phenotype; priority journal; RNA sequence; telencephalon; anatomy and histology; brain cortex; cytology; gene expression regulation; genetics; growth, development and aging; nerve cell; physiology; Mammalia; Cerebral Cortex; Gene Expression Regulation, Developmental; Humans; Neurogenesis; Neuroglia; Neurons; Telencephalon
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/244918
作者单位	Department of Neurology, University of California, San Francisco (UCSF), San Francisco, CA, United States; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, UCSF, San Francisco, CA, United States; Department of Anatomy, UCSF, San Francisco, CA, United States; Genomics Institute, University of California, Santa Cruz, CA, United States; Department of Neurosurgery, UCSF, San Francisco, CA, United States; New Technologies, Fluidigm, South San Francisco, CA, United States
推荐引用方式 GB/T 7714	Nowakowski T.J.,Bhaduri A.,Pollen A.A.,et al. Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex[J],2017,358(6368).
APA	Nowakowski T.J..,Bhaduri A..,Pollen A.A..,Alvarado B..,Mostajo-Radji M.A..,...&Kriegstein A.R..(2017).Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex.Science,358(6368).
MLA	Nowakowski T.J.,et al."Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex".Science 358.6368(2017).