气候变化领域集成服务门户(CCPortal): Transient cortical circuits match spontaneous and sensory-driven activity during development

CCPortal

DOI	10.1126/science.abb2153
	Transient cortical circuits match spontaneous and sensory-driven activity during development
	Molnár Z.; Luhmann H.J.; Kanold P.O.
发表日期	2020
ISSN	0036-8075
卷号	370 期号:6514
英文摘要	At the earliest developmental stages, spontaneous activity synchronizes local and large-scale cortical networks. These networks form the functional template for the establishment of global thalamocortical networks and cortical architecture. The earliest connections are established autonomously. However, activity from the sensory periphery reshapes these circuits as soon as afferents reach the cortex. The early-generated, largely transient neurons of the subplate play a key role in integrating spontaneous and sensory-driven activity. Early pathological conditions-such as hypoxia, inflammation, or exposure to pharmacological compounds-alter spontaneous activity patterns, which subsequently induce disturbances in cortical network activity. This cortical dysfunction may lead to local and global miswiring and, at later stages, can be associated with neurological and psychiatric conditions. © 2020 American Association for the Advancement of Science. All rights reserved.
英文关键词	anoxic conditions; biological development; developmental stage; pathology; psychology; sensory system; brain development; brain maturation; cortical synchronization; disease association; encephalitis; GABAergic system; gap junction; human; hypoxia; nerve cell differentiation; nerve cell necrosis; nerve cell network; nerve projection; nonhuman; priority journal; Review; sensory system; synapse; animal; apoptosis; brain cortex; claustrum; embryology; mouse; nerve cell plasticity; nerve tract; nervous system development; nuclear magnetic resonance imaging; pathophysiology; physiology; schizophrenia; thalamus nucleus; Animals; Apoptosis; Cerebral Cortex; Claustrum; Humans; Magnetic Resonance Imaging; Mice; Neural Pathways; Neurogenesis; Neuronal Plasticity; Schizophrenia; Thalamic Nuclei
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/244799
作者单位	Department of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Parks Road, Oxford, OX1 3PT, United Kingdom; Institute of Physiology, University Medical Center of the Johannes Gutenberg University Mainz, Duesbergweg 6, Mainz, 55128, Germany; Department of Biomedical Engineering, Johns Hopkins University, School of Medicine, 720 Rutland Avenue, MRB 379, Baltimore, MD 21205, United States; Johns Hopkins University Kavli Neuroscience Discovery Institute, Baltimore, MD 21205, United States
推荐引用方式 GB/T 7714	Molnár Z.,Luhmann H.J.,Kanold P.O.. Transient cortical circuits match spontaneous and sensory-driven activity during development[J],2020,370(6514).
APA	Molnár Z.,Luhmann H.J.,&Kanold P.O..(2020).Transient cortical circuits match spontaneous and sensory-driven activity during development.Science,370(6514).
MLA	Molnár Z.,et al."Transient cortical circuits match spontaneous and sensory-driven activity during development".Science 370.6514(2020).