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DOI	10.1126/science.aay6485
	Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens
	Mina M.J.; Kula T.; Leng Y.; Li M.; De Vries R.D.; Knip M.; Siljander H.; Rewers M.; Choy D.F.; Wilson M.S.; Benjamin Larman H.; Nelson A.N.; Griffin D.E.; De Swart R.L.; Elledge S.J.
发表日期	2019
ISSN	0036-8075
起始页码	599
结束页码	606
卷号	366 期号:6465
英文摘要	Measles virus is directly responsible for more than 100,000 deaths yearly. Epidemiological studies have associated measles with increased morbidity and mortality for years after infection, but the reasons why are poorly understood. Measles virus infects immune cells, causing acute immune suppression. To identify and quantify long-term effects of measles on the immune system, we used VirScan, an assay that tracks antibodies to thousands of pathogen epitopes in blood. We studied 77 unvaccinated children before and 2 months after natural measles virus infection. Measles caused elimination of 11 to 73% of the antibody repertoire across individuals. Recovery of antibodies was detected after natural reexposure to pathogens. Notably, these immune system effects were not observed in infants vaccinated against MMR (measles, mumps, and rubella), but were confirmed in measles-infected macaques. The reduction in humoral immune memory after measles infection generates potential vulnerability to future infections, underscoring the need for widespread vaccination. © 2019 American Association for the Advancement of Science. All rights reserved.
英文关键词	antibody; epitope; measles mumps rubella vaccine; bacterium antibody; epitope; measles mumps rubella vaccine; virus antibody; antibody; bioassay; cell; epidemiology; infectious disease; measles; morbidity; mortality; pathogen; adult; animal experiment; animal model; antibody titer; antigen recognition; Article; blood; child; cohort analysis; controlled study; disease severity; human; humoral immunity; immune deficiency; immune system; immunoassay; immunological memory; infant; infection sensitivity; infectious agent; Macaca; major clinical study; measles; nonhuman; priority journal; adolescent; animal; antibody specificity; blood; immunological memory; immunological tolerance; immunology; male; measles; preschool child; rhesus monkey; Macaca; Measles virus; Adolescent; Animals; Antibodies, Bacterial; Antibodies, Viral; Antibody Diversity; Child; Child, Preschool; Epitopes; Humans; Immune Tolerance; Immunologic Memory; Macaca mulatta; Male; Measles; Measles-Mumps-Rubella Vaccine
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/244787
作者单位	Division of Genetics, Brigham and Women’s Hospital, Howard Hughes Medical Institute, Boston, MA 02115, United States; Department of Genetics, Harvard Medical School, Boston, MA 02115, United States; Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, United States; Department of Viroscience, Postgraduate School of Molecular Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, 3015 CN, Netherlands; Children’s Hospital, University of Helsinki, Helsinki University Hospital, Helsinki, 00290, Finland; Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, 00014, Finland; Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Denver, CO 80045, United States; Genentech Inc., South San Francisco, CA 94080, United States; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States; W. Harry Feinstone Department of Molecular Microbiology and Immun...
推荐引用方式 GB/T 7714	Mina M.J.,Kula T.,Leng Y.,et al. Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens[J],2019,366(6465).
APA	Mina M.J..,Kula T..,Leng Y..,Li M..,De Vries R.D..,...&Elledge S.J..(2019).Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens.Science,366(6465).
MLA	Mina M.J.,et al."Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens".Science 366.6465(2019).