气候变化领域集成服务门户(CCPortal): Cerebrospinal fluid influx drives acute ischemic tissue swelling

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DOI	10.1126/science.aaw7462
	Cerebrospinal fluid influx drives acute ischemic tissue swelling
	Mestre H.; Du T.; Sweeney A.M.; Liu G.; Samson A.J.; Peng W.; Mortensen K.N.; Stæger F.F.; Bork P.A.R.; Bashford L.; Toro E.R.; Tithof J.; Kelley D.H.; Thomas J.H.; Hjorth P.G.; Martens E.A.; Mehta R.I.; Solis O.; Blinder P.; Kleinfeld D.; Hirase H.; Mori Y.; Nedergaard M.
发表日期	2020
ISSN	0036-8075
卷号	367 期号:6483
英文摘要	Stroke affects millions each year. Poststroke brain edema predicts the severity of eventual stroke damage, yet our concept of how edema develops is incomplete and treatment options remain limited. In early stages, fluid accumulation occurs owing to a net gain of ions, widely thought to enter from the vascular compartment. Here, we used magnetic resonance imaging, radiolabeled tracers, and multiphoton imaging in rodents to show instead that cerebrospinal fluid surrounding the brain enters the tissue within minutes of an ischemic insult along perivascular flow channels. This process was initiated by ischemic spreading depolarizations along with subsequent vasoconstriction, which in turn enlarged the perivascular spaces and doubled glymphatic inflow speeds. Thus, our understanding of poststroke edema needs to be revised, and these findings could provide a conceptual basis for development of alternative treatment strategies. © 2020 American Association for the Advancement of Science. All rights reserved.
英文关键词	brain; conceptual framework; inflow; stroke; swelling; adult; animal cell; animal experiment; animal model; animal tissue; Article; autopsy; brain cell; brain ischemia; brain water; cerebrospinal fluid flow; controlled study; glymphatic system; histology; human; human tissue; isotope labeling; male; mouse; neuroimaging; nonhuman; nuclear magnetic resonance imaging; perivascular space; priority journal; vasoconstriction; Rodentia
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/244768
作者单位	Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, United States; Department of Neuroscience, University of Rochester Medical Center, Rochester, NY 14642, United States; School of Pharmacy, China Medical University, Shenyang, 110122, China; Department of Neurosurgery, Fourth Affiliated Hospital, China Medical University, Shenyang, 110032, China; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark; Department of Applied Mathematics and Computer Science, Technical University of Denmark, Richard Petersens Plads, Lyngby, 2800 Kgs, Denmark; Department of Mechanical Engineering, University of Rochester, Rochester, NY 14627, United States; Department of Pathology, Rush University, Chicago, IL 60612, United States; Rush Alzheimer's Disease Center, Rush University, Chicago, IL 60612, United States; Neurobiology, Biochemistry and Biophysics School, George...
推荐引用方式 GB/T 7714	Mestre H.,Du T.,Sweeney A.M.,et al. Cerebrospinal fluid influx drives acute ischemic tissue swelling[J],2020,367(6483).
APA	Mestre H..,Du T..,Sweeney A.M..,Liu G..,Samson A.J..,...&Nedergaard M..(2020).Cerebrospinal fluid influx drives acute ischemic tissue swelling.Science,367(6483).
MLA	Mestre H.,et al."Cerebrospinal fluid influx drives acute ischemic tissue swelling".Science 367.6483(2020).