气候变化领域集成服务门户(CCPortal): Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape

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DOI	10.1126/science.abf6950
	Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape
	McCarthy K.R.; Rennick L.J.; Nambulli S.; Robinson-McCarthy L.R.; Bain W.G.; Haidar G.; Paul Duprex W.
发表日期	2021
ISSN	0036-8075
起始页码	1139
结束页码	1142
卷号	371 期号:6534
英文摘要	Zoonotic pandemics, such as that caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can follow the spillover of animal viruses into highly susceptible human populations. The descendants of these viruses have adapted to the human host and evolved to evade immune pressure. Coronaviruses acquire substitutions more slowly than other RNA viruses. In the spike glycoprotein, we found that recurrent deletions overcome this slow substitution rate. Deletion variants arise in diverse genetic and geographic backgrounds, transmit efficiently, and are present in novel lineages, including those of current global concern. They frequently occupy recurrent deletion regions (RDRs), which map to defined antibody epitopes. Deletions in RDRs confer resistance to neutralizing antibodies. By altering stretches of amino acids, deletions appear to accelerate SARS-CoV-2 antigenic evolution and may, more generally, drive adaptive evolution. © 2021 American Association for the Advancement of Science. All rights reserved.
英文关键词	convalescent serum; coronavirus spike glycoprotein; dexamethasone; monoclonal antibody; neutralizing antibody; remdesivir; SARS CoV 2 spike glycoprotein; unclassified drug; vitronectin; coronavirus spike glycoprotein; neutralizing antibody; spike protein, SARS-CoV-2; virus antibody; virus antigen; antibiotic resistance; antibiotics; antibody; COVID-19; protein; severe acute respiratory syndrome; antigen binding; Article; cancer patient; codon; convergent evolution; coronavirus disease 2019; disease transmission; gene deletion; genetic variability; human; immunocompromised patient; in vitro study; nonhuman; phenotype; protein depletion; recurrent deletion region; S gene; Severe acute respiratory syndrome coronavirus 2; virus isolation; virus replication; amino acid sequence; amino acid substitution; chemistry; gene deletion; genetic drift; genetics; immune evasion; immunology; molecular evolution; protein conformation; virology; RNA viruses; SARS coronavirus; Amino Acid Sequence; Amino Acid Substitution; Antibodies, Neutralizing; Antibodies, Viral; Antigens, Viral; COVID-19; Evolution, Molecular; Genetic Drift; Humans; Immune Evasion; Protein Conformation; SARS-CoV-2; Sequence Deletion; Spike Glycoprotein, Coronavirus
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/244695
作者单位	Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; Laboratory of Molecular Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA, United States; Department of Genetics, Harvard Medical School, Boston, MA, United States; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, UPMC, Pittsburgh, PA, United States; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; VA Pittsburgh Healthcare System, Pittsburgh, PA, United States; Division of Infectious Disease, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; Division of Infectious Disease, Department of Internal Medicine, UPMC, Pittsburgh, PA, United States
推荐引用方式 GB/T 7714	McCarthy K.R.,Rennick L.J.,Nambulli S.,et al. Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape[J],2021,371(6534).
APA	McCarthy K.R..,Rennick L.J..,Nambulli S..,Robinson-McCarthy L.R..,Bain W.G..,...&Paul Duprex W..(2021).Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape.Science,371(6534).
MLA	McCarthy K.R.,et al."Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape".Science 371.6534(2021).