气候变化领域集成服务门户(CCPortal): Spermidine in health and disease

CCPortal

DOI	10.1126/science.aan2788
	Spermidine in health and disease
	Madeo F.; Eisenberg T.; Pietrocola F.; Kroemer G.
发表日期	2018
ISSN	0036-8075
卷号	359 期号:6374
英文摘要	Interventions that delay aging and protect from age-associated disease are slowly approaching clinical implementation. Such interventions include caloric restriction mimetics, which are defined as agents that mimic the beneficial effects of dietary restriction while limiting its detrimental effects. One such agent, the natural polyamine spermidine, has prominent cardioprotective and neuroprotective effects and stimulates anticancer immunosurveillance in rodent models. Moreover, dietary polyamine uptake correlates with reduced cardiovascular and cancer-related mortality in human epidemiological studies. Spermidine preserves mitochondrial function, exhibits anti-inflammatory properties, and prevents stem cell senescence. Mechanistically, it shares the molecular pathways engaged by other caloric restriction mimetics: It induces protein deacetylation and depends on functional autophagy. Because spermidine is already present in daily human nutrition, clinical trials aiming at increasing the uptake of this polyamine appear feasible. © 2017 The Authors.
英文关键词	arginine; nitric oxide; spermidine; neuroprotective agent; nonsteroid antiinflammatory agent; spermidine; cancer; cardiovascular disease; disease; epidemiology; immune response; molecular analysis; mortality; organic compound; aging; Alzheimer disease; antiinflammatory activity; antineoplastic activity; antioxidant activity; autophagy; biomimetics; caloric restriction; cancer inhibition; cancer mortality; carcinogenesis; cardiovascular disease; cardiovascular mortality; cell aging; cell function; deacetylation; diet; diseases; health; heart protection; human; immunomodulation; immunosurveillance; life extension; malignant neoplasm; metabolism; neuroprotection; non insulin dependent diabetes mellitus; nonhuman; nutrition; obesity; priority journal; Review; animal; caloric restriction; cardiovascular disease; dietary supplement; drug effects; metabolic syndrome X; physiology; transport at the cellular level; Rodentia; Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Autophagy; Biological Transport; Caloric Restriction; Carcinogenesis; Cardiovascular Diseases; Dietary Supplements; Humans; Metabolic Syndrome; Neuroprotective Agents; Spermidine
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/244616
作者单位	Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria; BioTechMed Graz, Graz, Austria; Equipe 11 Labellisée Ligue Contre le Cancer, Centre de Recherche des Cordeliers, Paris, France; Cell Biology and Metabolomics Platforms, Gustave Roussy Comprehensive Cancer Center, Villejuif, France; INSERM, Paris, U1138, France; University Paris Descartes, Sorbonne Paris Cité, Paris, France; University Pierre and Marie Curie, Paris, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, Paris, France; Department of Women's and Children's Health, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden
推荐引用方式 GB/T 7714	Madeo F.,Eisenberg T.,Pietrocola F.,et al. Spermidine in health and disease[J],2018,359(6374).
APA	Madeo F.,Eisenberg T.,Pietrocola F.,&Kroemer G..(2018).Spermidine in health and disease.Science,359(6374).
MLA	Madeo F.,et al."Spermidine in health and disease".Science 359.6374(2018).