气候变化领域集成服务门户(CCPortal): SARS-CoV-2 within-host diversity and transmission

CCPortal

DOI	10.1126/SCIENCE.ABG0821
	SARS-CoV-2 within-host diversity and transmission
	Lythgoe K.A.; Hall M.; Ferretti L.; de Cesare M.; MacIntyre-Cockett G.; Trebes A.; Andersson M.; Otecko N.; Wise E.L.; Moore N.; Lynch J.; Kidd S.; Cortes N.; Mori M.; Williams R.; Vernet G.; Justice A.; Green A.; Nicholls S.M.; Ansari M.A.; Abeler-Dörner L.; Moore C.E.; Peto T.E.A.; Eyre D.W.; Shaw R.; Simmonds P.; Buck D.; Todd J.A.; Connor T.R.; Ashraf S.; da Silva Filipe A.; Shepherd J.; Thomson E.C.; Bonsall D.; Fraser C.; Golubchik T.; Oxford Virus Sequencing Analysis Group (OVSG); COVID-19 Genomics UK (COG-UK) Consortium
发表日期	2021
ISSN	0036-8075
卷号	372 期号:6539
英文摘要	Extensive global sampling and sequencing of the pandemic virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have enabled researchers to monitor its spread and to identify concerning new variants. Two important determinants of variant spread are how frequently they arise within individuals and how likely they are to be transmitted. To characterize within-host diversity and transmission, we deep-sequenced 1313 clinical samples from the United Kingdom. SARS-CoV-2 infections are characterized by low levels of within-host diversity when viral loads are high and by a narrow bottleneck at transmission. Most variants are either lost or occasionally fixed at the point of transmission, with minimal persistence of shared diversity, patterns that are readily observable on the phylogenetic tree. Our results suggest that transmission-enhancing and/or immune-escape SARS-CoV-2 variants are likely to arise infrequently but could spread rapidly if successfully transmitted. © 2021 American Association for the Advancement of Science. All rights reserved.
英文关键词	disease transmission; persistence; phylogenetics; research work; sampling; severe acute respiratory syndrome; Article; controlled study; coronavirus disease 2019; disease transmission; gene sequence; genetic background; human; microbial diversity; mutation; nonhuman; phylogenetic tree; priority journal; Severe acute respiratory syndrome coronavirus 2; United Kingdom; virus load; virus transmission; Coronavirus infection; family size; genetic selection; genetic variation; genetics; Human coronavirus OC43; immune evasion; immunology; mixed infection; pathogenicity; phylogeny; physiology; virology; virus genome; United Kingdom; SARS coronavirus; Varanidae; coronavirus spike glycoprotein; spike protein, SARS-CoV-2; virus RNA; Coinfection; Coronavirus Infections; Coronavirus OC43, Human; COVID-19; Family Characteristics; Genetic Variation; Genome, Viral; Humans; Immune Evasion; Mutation; Phylogeny; RNA, Viral; RNA-Seq; SARS-CoV-2; Selection, Genetic; Spike Glycoprotein, Coronavirus; United Kingdom; Viral Load
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/244601
作者单位	Big Data Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, OX3 7LF, United Kingdom; Department of Zoology, University of Oxford, Oxford, OX1 3SZ, United Kingdom; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford, Old Road Campus, Oxford, OX3 7BN, United Kingdom; Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, United Kingdom; Division of Medical Virology, Stellenbosch University, Stellenbosch, South Africa; Hampshire Hospitals NHS Foundation Trust, Basingstoke and North Hampshire Hospital, Basingstoke, RG24 9NA, United Kingdom; School of Biosciences and Medicine, University of Surrey, Guildford, GU2 7XH, United Kingdom; Gibraltar Health Authorityn, Gibraltar, United Kingdom; School of Medicine, University of Southampton, Southampton, SO17 1BJ, United Kingdom; Institute of Microbiology and Infection, University of Birmingham, Birmingham, B1...
推荐引用方式 GB/T 7714	Lythgoe K.A.,Hall M.,Ferretti L.,et al. SARS-CoV-2 within-host diversity and transmission[J],2021,372(6539).
APA	Lythgoe K.A..,Hall M..,Ferretti L..,de Cesare M..,MacIntyre-Cockett G..,...&COVID-19 Genomics UK .(2021).SARS-CoV-2 within-host diversity and transmission.Science,372(6539).
MLA	Lythgoe K.A.,et al."SARS-CoV-2 within-host diversity and transmission".Science 372.6539(2021).