气候变化领域集成服务门户(CCPortal): Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus

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DOI	10.1126/science.aat8789
	Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus
	Luna V.M.; Anacker C.; Burghardt N.S.; Khandaker H.; Andreu V.; Millette A.; Leary P.; Ravenelle R.; Jimenez J.C.; Mastrodonato A.; Denny C.A.; Fenton A.A.; Scharfman H.E.; Hen R.
发表日期	2019
ISSN	0036-8075
起始页码	578
结束页码	583
卷号	364 期号:6440
英文摘要	Young adult-born granule cells (abGCs) in the dentate gyrus (DG) have a profound impact on cognition and mood. However, it remains unclear how abGCs distinctively contribute to local DG information processing.We found that the actions of abGCs in the DG depend on the origin of incoming afferents. In response to lateral entorhinal cortex (LEC) inputs, abGCs exert monosynaptic inhibition of mature granule cells (mGCs) through group II metabotropic glutamate receptors. By contrast, in response to medial entorhinal cortex (MEC) inputs, abGCs directly excite mGCs through N-methyl-D-aspartate receptors. Thus, a critical function of abGCs may be to regulate the relative synaptic strengths of LEC-driven contextual information versus MEC-driven spatial information to shape distinct neural representations in the DG. © 2019 American Association for the Advancement of Science. All rights reserved.
英文关键词	adult; brain; cell component; information; inhibition; nervous system; protein; animal cell; animal tissue; Article; brain nerve cell; controlled study; dentate gyrus; entorhinal cortex; evoked response; feedback system; firing rate; hippocampus; mouse; nerve cell plasticity; nervous system development; nonhuman; postsynaptic density; priority journal; synaptic potential; animal; cell culture; dentate gyrus; entorhinal cortex; hippocampus; human; nerve cell; physiology; synapse; transgenic mouse; n methyl dextro aspartic acid receptor; Animals; Cells, Cultured; Dentate Gyrus; Entorhinal Cortex; Evoked Potentials; Hippocampus; Humans; Mice; Mice, Transgenic; Neurons; Receptors, N-Methyl-D-Aspartate; Synapses
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/244594
作者单位	Division of Systems Neuroscience, Department of Psychiatry, Columbia University, Research Foundation for Mental Hygiene, New York State Psychiatric Institute, New York, NY 10032, United States; Sackler Institute for Developmental Psychobiology, New York, NY 10065, United States; Department of Psychology, Hunter College, City University of New York, New York, NY 10021, United States; Department of Psychology, Graduate Center, City University of New York, New York, NY 10016, United States; Departments of Child and Adolescent Psychiatry, Neuroscience and Physiology, Psychiatry and the Neuroscience Institute, New York University Langone Health, New York, NY 10016, United States; Department of Biology, Graduate Center, City University of New York, New York, NY 10021, United States; Center for Neural Science, New York University, New York, NY 10003, United States; State University of New York Downstate Medical Center, Brooklyn, NY 11203, United States
推荐引用方式 GB/T 7714	Luna V.M.,Anacker C.,Burghardt N.S.,et al. Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus[J],2019,364(6440).
APA	Luna V.M..,Anacker C..,Burghardt N.S..,Khandaker H..,Andreu V..,...&Hen R..(2019).Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus.Science,364(6440).
MLA	Luna V.M.,et al."Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus".Science 364.6440(2019).