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DOI	10.1126/science.abb2169
	Apical stress fibers enable a scaling between cell mechanical response and area in epithelial tissue
	López-Gay J.M.; Nunley H.; Spencer M.; di Pietro F.; Guirao B.; Bosveld F.; Markova O.; Gaugue I.; Pelletier S.; Lubensky D.K.; Bellaïche Y.
发表日期	2020
ISSN	0036-8075
卷号	370 期号:6514
英文摘要	Biological systems tailor their properties and behavior to their size throughout development and in numerous aspects of physiology. However, such size scaling remains poorly understood as it applies to cell mechanics and mechanosensing. By examining how the Drosophila pupal dorsal thorax epithelium responds to morphogenetic forces, we found that the number of apical stress fibers (aSFs) anchored to adherens junctions scales with cell apical area to limit larger cell elongation under mechanical stress. aSFs cluster Hippo pathway components, thereby scaling Hippo signaling and proliferation with area. This scaling is promoted by tricellular junctions mediating an increase in aSF nucleation rate and lifetime in larger cells. Development, homeostasis, and repair entail epithelial cell size changes driven by mechanical forces; our work highlights how, in turn, mechanosensitivity scales with cell size. © 2020 American Association for the Advancement of Science. All rights reserved.
英文关键词	biomechanics; cell; homeostasis; morphogenesis; muscle; nucleation; physiology; actomyosin contractility; adherens junction; animal cell; apical stress fiber; Article; cell elongation; cell function; cell proliferation; cell size; computer simulation; controlled study; Drosophila; epithelium; hippo signaling; mechanical stress; morphogenesis; nonhuman; priority journal; stress fiber; tricellular junction; animal; cell size; Drosophila melanogaster; epithelium; epithelium cell; mechanical stress; mechanotransduction; metabolism; physiology; stress fiber; cadherin; Drosophila protein; hpo protein, Drosophila; myosin II; nuclear protein; protein serine threonine kinase; shg protein, Drosophila; signal peptide; transactivator protein; Yki protein, Drosophila; Animals; Cadherins; Cell Size; Drosophila melanogaster; Drosophila Proteins; Epithelial Cells; Epithelium; Intracellular Signaling Peptides and Proteins; Mechanotransduction, Cellular; Myosin Type II; Nuclear Proteins; Protein-Serine-Threonine Kinases; Stress Fibers; Stress, Mechanical; Trans-Activators
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/244576
作者单位	Institut Curie, PSL Research University, CNRS UMR 3215, INSERM U934, Paris Cedex 05, F-75248, France; Sorbonne Universités, UPMC Univ Paris 06, CNRS, CNRS UMR 3215, INSERM U934, Paris, F-75005, France; Biophysics Program, University of Michigan, Ann Arbor, MI 48109, United States; Department of Physics, University of Michigan, Ann Arbor, MI 48109, United States
推荐引用方式 GB/T 7714	López-Gay J.M.,Nunley H.,Spencer M.,et al. Apical stress fibers enable a scaling between cell mechanical response and area in epithelial tissue[J],2020,370(6514).
APA	López-Gay J.M..,Nunley H..,Spencer M..,di Pietro F..,Guirao B..,...&Bellaïche Y..(2020).Apical stress fibers enable a scaling between cell mechanical response and area in epithelial tissue.Science,370(6514).
MLA	López-Gay J.M.,et al."Apical stress fibers enable a scaling between cell mechanical response and area in epithelial tissue".Science 370.6514(2020).