气候变化领域集成服务门户(CCPortal): Diversity and functional landscapes in the microbiota of animals in the wild

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DOI	10.1126/SCIENCE.ABB5352
	Diversity and functional landscapes in the microbiota of animals in the wild
	Levin D.; Raab N.; Pinto Y.; Rothschild D.; Zanir G.; Godneva A.; Mellul N.; Futorian D.; Gal D.; Leviatan S.; Zeevi D.; Bachelet I.; Segal E.
发表日期	2021
ISSN	0036-8075
卷号	372 期号:6539
英文摘要	Animals in the wild are able to subsist on pathogen-infected and poisonous food and show immunity to various diseases. These may be due to their microbiota, yet we have a poor understanding of animal microbial diversity and function. We used metagenomics to analyze the gut microbiota of more than 180 species in the wild, covering diverse classes, feeding behaviors, geographies, and traits. Using de novo metagenome assembly, we constructed and functionally annotated a database of more than 5000 genomes, comprising 1209 bacterial species of which 75% are unknown. The microbial composition, diversity, and functional content exhibit associations with animal taxonomy, diet, activity, social structure, and life span. We identify the gut microbiota of wild animals as a largely untapped resource for the discovery of therapeutics and biotechnology applications. © 2021 American Association for the Advancement of Science. All rights reserved.
英文关键词	bacterium; biotechnology; database; genetic analysis; immunity; microbial community; pathogen; species diversity; animal behavior; animal food; animal structures; animal welfare; animal well-being; Article; feeding behavior; genome; geography; immunity; intestine flora; landscape; lifespan; metagenomics; microbial activity; microbial diversity; microflora; nonhuman; priority journal; species diversity; taxonomy; wild animal; wildlife; animal; bacterial genome; bacterium; biodiversity; classification; diet; ecosystem; Falkland Islands (Malvinas); feces; genetics; intestine flora; isolation and purification; Israel; Madagascar; metabolism; metagenome; microbiology; nucleic acid database; phylogeny; physiology; Queensland; Uganda; wild animal; Bacteria (microorganisms); Microbiota; bacterial toxin; peptide hydrolase; Animals; Animals, Wild; Bacteria; Bacterial Toxins; Behavior, Animal; Biodiversity; Databases, Nucleic Acid; Diet; Ecosystem; Falkland Islands; Feces; Gastrointestinal Microbiome; Genome, Bacterial; Host Microbial Interactions; Israel; Madagascar; Metagenome; Metagenomics; Peptide Hydrolases; Phylogeny; Queensland; Uganda
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/244512
作者单位	Wild Biotech, Rehovot, Israel; Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, 7610001, Israel; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, 7610001, Israel; Department of Developmental Biology, Stanford University, Stanford, CA 94305, United States; Department of Genetics, Stanford University, Stanford, CA 94305, United States; Augmanity, Rehovot, Israel; Center for Studies in Physics and Biology, Rockefeller University, New York, NY 10065, United States
推荐引用方式 GB/T 7714	Levin D.,Raab N.,Pinto Y.,et al. Diversity and functional landscapes in the microbiota of animals in the wild[J],2021,372(6539).
APA	Levin D..,Raab N..,Pinto Y..,Rothschild D..,Zanir G..,...&Segal E..(2021).Diversity and functional landscapes in the microbiota of animals in the wild.Science,372(6539).
MLA	Levin D.,et al."Diversity and functional landscapes in the microbiota of animals in the wild".Science 372.6539(2021).