气候变化领域集成服务门户(CCPortal): Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events

CCPortal

DOI	10.1126/science.abe3261
	Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events
	Lemieux J.E.; Siddle K.J.; Shaw B.M.; Loreth C.; Schaffner S.F.; Gladden-Young A.; Adams G.; Fink T.; Tomkins-Tinch C.H.; Krasilnikova L.A.; DeRuff K.C.; Rudy M.; Bauer M.R.; Lagerborg K.A.; Normandin E.; Chapman S.B.; Reilly S.K.; Anahtar M.N.; Lin A.E.; Carter A.; Myhrvold C.; Kemball M.E.; Chaluvadi S.; Cusick C.; Flowers K.; Neumann A.; Cerrato F.; Farhat M.; Slater D.; Harris J.B.; Branda J.A.; Hooper D.; Gaeta J.M.; Baggett T.P.; O'Connell J.; Gnirke A.; Lieberman T.D.; Philippakis A.; Burns M.; Brown C.M.; Luban J.; Ryan E.T.; Turbett S.E.; LaRocque R.C.; Hanage W.P.; Gallagher G.R.; Madoff L.C.; Smole S.; Pierce V.M.; Rosenberg E.; Sabeti P.C.; Park D.J.; MacInnis B.L.
发表日期	2021
ISSN	0036-8075
卷号	371 期号:6529
英文摘要	Analysis of 772 complete severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes from early in the Boston-area epidemic revealed numerous introductions of the virus, a small number of which led to most cases. The data revealed two superspreading events. One, in a skilled nursing facility, led to rapid transmission and significant mortality in this vulnerable population but little broader spread, whereas other introductions into the facility had little effect. The second, at an international business conference, produced sustained community transmission and was exported, resulting in extensive regional, national, and international spread. The two events also differed substantially in the genetic variation they generated, suggesting varying transmission dynamics in superspreading events. Our results show how genomic epidemiology can help to understand the link between individual clusters and wider community spread. © 2021 American Association for the Advancement of Science. All rights reserved.
英文关键词	epidemic; genome; mortality; phylogenetics; severe acute respiratory syndrome; vulnerability; article; community transmission; genetic variation; human; Massachusetts; nonhuman; phylogeny; Severe acute respiratory syndrome coronavirus 2; superspreading event; epidemic; epidemiological monitoring; epidemiology; genetics; Massachusetts; virus genome; Boston; Massachusetts; United States; SARS coronavirus; Boston; COVID-19; Disease Outbreaks; Epidemiological Monitoring; Genome, Viral; Humans; Phylogeny; SARS-CoV-2
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/244495
作者单位	Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, United States; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, United States; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, United States; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, United States; Massachusetts Department of Public Health, Boston, MA, United States; Harvard Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, United States; Department of Systems Biology, Harvard Medical School, Boston, MA, United States; Department of Pathology, Massachusetts General Hospital, Boston, MA, United States; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, United States; Division of Pulmonary and Critical Care, Massachusetts General Hospital, Boston, MA, United States; Department of Pediatrics, Harvard Medical School, B...
推荐引用方式 GB/T 7714	Lemieux J.E.,Siddle K.J.,Shaw B.M.,et al. Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events[J],2021,371(6529).
APA	Lemieux J.E..,Siddle K.J..,Shaw B.M..,Loreth C..,Schaffner S.F..,...&MacInnis B.L..(2021).Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events.Science,371(6529).
MLA	Lemieux J.E.,et al."Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events".Science 371.6529(2021).