气候变化领域集成服务门户(CCPortal): Immunological characteristics govern the transition of COVID-19 to endemicity

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DOI	10.1126/science.abe6522
	Immunological characteristics govern the transition of COVID-19 to endemicity
	Lavine J.S.; Bjornstad O.N.; Antia R.
发表日期	2021
ISSN	0036-8075
卷号	371 期号:6530
英文摘要	We are currently faced with the question of how the severity of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may change in the years ahead. Our analysis of immunological and epidemiological data on endemic human coronaviruses (HCoVs) shows that infection-blocking immunity wanes rapidly but that disease-reducing immunity is long-lived. Our model, incorporating these components of immunity, recapitulates both the current severity of SARS-CoV-2 infection and the benign nature of HCoVs, suggesting that once the endemic phase is reached and primary exposure is in childhood, SARS-CoV-2 may be no more virulent than the common cold. We predict a different outcome for an emergent coronavirus that causes severe disease in children. These results reinforce the importance of behavioral containment during pandemic vaccine rollout, while prompting us to evaluate scenarios for continuing vaccination in the endemic phase. Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works
英文关键词	child health; COVID-19; disease severity; endemism; immune system; immunity; infectious disease; vaccination; viral disease; Article; causal attribution; coronavirus disease 2019; disease burden; disease severity; endemic disease; human; immune response; molecular evolution; nonhuman; pandemic; reinfection; seroprevalence; Severe acute respiratory syndrome coronavirus 2; social distancing; T lymphocyte; virus infectivity; virus strain; virus transmission; adaptive immunity; adolescent; adult; age distribution; blood; child; communicable disease; Coronavirinae; Coronavirus infection; endemic disease; epidemic; immunology; infant; mortality; pathogenicity; preschool child; prevention and control; seroepidemiology; severe acute respiratory syndrome; severity of illness index; Coronavirus; SARS coronavirus; immunoglobulin G; immunoglobulin M; virus antibody; Adaptive Immunity; Adolescent; Adult; Age Distribution; Antibodies, Viral; Child; Child, Preschool; Communicable Diseases, Emerging; Coronavirus; Coronavirus Infections; COVID-19; COVID-19 Vaccines; Endemic Diseases; Epidemics; Humans; Immunoglobulin G; Immunoglobulin M; Infant; Reinfection; SARS-CoV-2; Seroepidemiologic Studies; Severe Acute Respiratory Syndrome; Severity of Illness Index
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/244465
作者单位	Department of Biology, Emory University, Atlanta, GA 30322, United States; Department of Biology, Center for Infectious Disease Dynamics, Pennsylvania State University, University Park, PA 16802, United States
推荐引用方式 GB/T 7714	Lavine J.S.,Bjornstad O.N.,Antia R.. Immunological characteristics govern the transition of COVID-19 to endemicity[J],2021,371(6530).
APA	Lavine J.S.,Bjornstad O.N.,&Antia R..(2021).Immunological characteristics govern the transition of COVID-19 to endemicity.Science,371(6530).
MLA	Lavine J.S.,et al."Immunological characteristics govern the transition of COVID-19 to endemicity".Science 371.6530(2021).