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| DOI | 10.1126/science.aaz5667 |
| Exploring whole-genome duplicate gene retention with complex genetic interaction analysis | |
| Kuzmin E.; Vandersluis B.; Ba A.N.N.; Wang W.; Koch E.N.; Usaj M.; Khmelinskii A.; Usaj M.M.; Leeuwen J.V.; Kraus O.; Tresenrider A.; Pryszlak M.; Hu M.-C.; Varriano B.; Costanzo M.; Knop M.; Moses A.; Myers C.L.; Andrews B.J.; Boone C. | |
| 发表日期 | 2020 |
| ISSN | 0036-8075 |
| 卷号 | 368期号:6498 |
| 英文摘要 | Whole-genome duplication has played a central role in the genome evolution of many organisms, including the human genome. Most duplicated genes are eliminated, and factors that influence the retention of persisting duplicates remain poorly understood. We describe a systematic complex genetic interaction analysis with yeast paralogs derived from the whole-genome duplication event. Mapping of digenic interactions for a deletion mutant of each paralog, and of trigenic interactions for the double mutant, provides insight into their roles and a quantitative measure of their functional redundancy. Trigenic interaction analysis distinguishes two classes of paralogs: A more functionally divergent subset and another that retained more functional overlap. Gene feature analysis and modeling suggest that evolutionary trajectories of duplicated genes are dictated by combined functional and structural entanglement factors. © 2020 American Association for the Advancement of Science. All rights reserved. |
| 英文关键词 | gene expression; genetic analysis; genome; mutation; quantitative analysis; yeast; article; duplicate gene; gene deletion; gene interaction; human; nonhuman; paralogy; quantitative analysis; structure activity relation; yeast; fungal genome; gene duplication; gene regulatory network; genetic procedures; genetics; protein analysis; Saccharomyces cerevisiae; membrane protein; peroxin; PEX25 protein, S cerevisiae; Pex27 protein, S cerevisiae; Saccharomyces cerevisiae protein; Gene Deletion; Gene Duplication; Gene Regulatory Networks; Genes, Duplicate; Genetic Techniques; Genome, Fungal; Membrane Proteins; Peroxins; Protein Interaction Maps; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins |
| 语种 | 英语 |
| 来源期刊 | Science
 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/244430 |
| 作者单位 | Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 3E1, Canada; Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN 55455, United States; Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada; Center for Analysis of Evolution and Function, University of Toronto, Toronto, ON, Canada; Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, 69120, Germany; Department of Molecular and Cell Biology, University of California, Berkeley, CA, United States; German Cancer Research Center (DKFZ), Cell Morphogenesis and Signal Transduction, Heidelberg, 69120, Germany; Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, Canada; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, H3A 1A3, Canada; Department of Organismic and Evolutionary Biology, Harva... |
| 推荐引用方式 GB/T 7714 | Kuzmin E.,Vandersluis B.,Ba A.N.N.,et al. Exploring whole-genome duplicate gene retention with complex genetic interaction analysis[J],2020,368(6498). |
| APA | Kuzmin E..,Vandersluis B..,Ba A.N.N..,Wang W..,Koch E.N..,...&Boone C..(2020).Exploring whole-genome duplicate gene retention with complex genetic interaction analysis.Science,368(6498). |
| MLA | Kuzmin E.,et al."Exploring whole-genome duplicate gene retention with complex genetic interaction analysis".Science 368.6498(2020). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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