气候变化领域集成服务门户(CCPortal): Antigenic evolution of dengue viruses over 20 years

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DOI	10.1126/science.abk0058
	Antigenic evolution of dengue viruses over 20 years
	Katzelnick L.C.; Escoto A.C.; Huang A.T.; Garcia-Carreras B.; Chowdhury N.; Berry I.M.; Chavez C.; Buchy P.; Duong V.; Dussart P.; Gromowski G.; Macareo L.; Thaisomboonsuk B.; Fernandez S.; Smith D.J.; Jarman R.; Whitehead S.S.; Salje H.; Cummings D.A.T.
发表日期	2021
ISSN	0036-8075
起始页码	999
结束页码	1004
卷号	374 期号:6570
英文摘要	Infection with one of dengue viruses 1 to 4 (DENV1-4) induces protective antibodies against homotypic infection. However, a notable feature of dengue viruses is the ability to use preexisting heterotypic antibodies to infect Fcg receptor–bearing immune cells, leading to higher viral load and immunopathological events that augment disease. We tracked the antigenic dynamics of each DENV serotype by using 1944 sequenced isolates from Bangkok, Thailand, between 1994 and 2014 (348 strains), in comparison with regional and global DENV antigenic diversity (64 strains). Over the course of 20 years, the Thailand DENV serotypes gradually evolved away from one another. However, for brief periods, the serotypes increased in similarity, with corresponding changes in epidemic magnitude. Antigenic evolution within a genotype involved a trade-off between two types of antigenic change (within-serotype and between-serotype), whereas genotype replacement resulted in antigenic change away from all serotypes. These findings provide insights into theorized dynamics in antigenic evolution. © 2021 American Association for the Advancement of Science. All rights reserved.
英文关键词	antibody; antigen; genotype; infectious disease; virus; animal cell; antigenic variation; antigenicity; Article; controlled study; Dengue virus; epidemic; gene sequence; genotype; immunocompetent cell; nonhuman; phylogenetic tree; serotype; Thailand; virus isolation; virus load; virus strain; Bangkok; Central Region [Thailand]; Krung Thep Mahanakhon; Thailand; Dengue virus group
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/244232
作者单位	Department of Biology and Emerging Pathogens Institute, University of Florida, Gainesville, FL 32611, United States; Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, United States; Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, United States; GlaxoSmithKline (GSK) Vaccines, Singapore, 637421, Singapore; Institut Pasteur in Cambodia, Réseau International des Instituts Pasteur, Phnom Penh, 12201, Cambodia; Department of Zoology, University of Cambridge, Cambridge, CB2 3EJ, United Kingdom; Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, United States; Department of Genetics, University of Cambridge, Cambridge, CB2 3EJ, United Kingdom
推荐引用方式 GB/T 7714	Katzelnick L.C.,Escoto A.C.,Huang A.T.,et al. Antigenic evolution of dengue viruses over 20 years[J],2021,374(6570).
APA	Katzelnick L.C..,Escoto A.C..,Huang A.T..,Garcia-Carreras B..,Chowdhury N..,...&Cummings D.A.T..(2021).Antigenic evolution of dengue viruses over 20 years.Science,374(6570).
MLA	Katzelnick L.C.,et al."Antigenic evolution of dengue viruses over 20 years".Science 374.6570(2021).