气候变化领域集成服务门户(CCPortal): Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse

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DOI	10.1126/science.1144233
	Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse
	Hu J.; Zhong C.; Ding C.; Chi Q.; Walz A.; Mombaerts P.; Matsunami H.; Luo M.
发表日期	2007
ISSN	0036-8075
起始页码	953
结束页码	957
卷号	317 期号:5840
英文摘要	Carbon dioxide (CO2) is an important environmental cue for many organisms but is odorless to humans. It remains unclear whether the mammalian olfactory system can detect CO2 at concentrations around the average atmospheric level (0.038%). We demonstrated the expression of carbonic anhydrase type II (CAII), an enzyme that catabolizes CO2, in a subset of mouse olfactory neurons that express guanylyl cyclase D (GC-D+ neurons) and project axons to necklace glomeruli in the olfactory bulb. Exposure to CO2 activated these GC-D+ neurons, and exposure of a mouse to CO2 activated bulbar neurons associated with necklace glomeruli. Behavioral tests revealed CO2 detection thresholds of ∼0.066%, and this sensitive CO2 detection required CAII activity. We conclude that mice detect CO2 at near-atmospheric concentrations through the olfactory subsystem of GC-D+ neurons.
英文关键词	carbon dioxide; carbonate dehydratase II; guanylate cyclase; guanylate cyclase D; unclassified drug; atmospheric gas; behavioral response; carbon dioxide; chemical cue; enzyme activity; gene expression; odor; olfaction; rodent; threshold; animal experiment; article; atmosphere; behavior; controlled study; enzyme activity; mouse; necklace glomeruli; nerve cell; nerve fiber; nervous system function; nonhuman; olfactory bulb; olfactory nerve; olfactory system; perceptive threshold; priority journal; protein expression; sensitivity analysis; sensory analysis; stimulus response; Animals; Carbon Dioxide; Carbonic Anhydrase II; Cyclic GMP; Gene Expression Profiling; Guanylate Cyclase; Ion Channels; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mutation; Neurons; Odors; Olfactory Bulb; Olfactory Mucosa; Olfactory Receptor Neurons; Phosphoric Diester Hydrolases; Mammalia; Mus
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/244083
作者单位	National Institute of Biological Sciences, Beijing, 102206, China; Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, United States; Rockefeller University, 1230 York Avenue, New York, NY 10021, United States
推荐引用方式 GB/T 7714	Hu J.,Zhong C.,Ding C.,et al. Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse[J],2007,317(5840).
APA	Hu J..,Zhong C..,Ding C..,Chi Q..,Walz A..,...&Luo M..(2007).Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse.Science,317(5840).
MLA	Hu J.,et al."Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse".Science 317.5840(2007).