气候变化领域集成服务门户(CCPortal): Complement factor C1q mediates sleep spindle loss and epileptic spikes after mild brain injury

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DOI	10.1126/science.abj2685
	Complement factor C1q mediates sleep spindle loss and epileptic spikes after mild brain injury
	Holden S.S.; Grandi F.C.; Aboubakr O.; Higashikubo B.; Cho F.S.; Chang A.H.; Forero A.O.; Morningstar A.R.; Mathur V.; Kuhn L.J.; Suri P.; Sankaranarayanan S.; Andrews-Zwilling Y.; Tenner A.J.; Luthi A.; Aronica E.; Corces M.R.; Yednock T.; Paz J.T.
发表日期	2021
ISSN	0036-8075
卷号	373 期号:6560
英文摘要	Although traumatic brain injury (TBI) acutely disrupts the cortex, most TBI-related disabilities reflect secondary injuries that accrue over time. The thalamus is a likely site of secondary damage because of its reciprocal connections with the cortex. Using a mouse model of mild TBI (mTBI), we found a chronic increase in C1q expression specifically in the corticothalamic system. Increased C1q expression colocalized with neuron loss and chronic inflammation and correlated with disruption in sleep spindles and emergence of epileptic activities. Blocking C1q counteracted these outcomes, suggesting that C1q is a disease modifier in mTBI. Single-nucleus RNA sequencing demonstrated that microglia are a source of thalamic C1q. The corticothalamic circuit could thus be a new target for treating TBI-related disabilities. © 2021 American Association for the Advancement of Science. All rights reserved.
英文关键词	brain; disability; disease; emergence; injury; RNA; sleep; Elliptio dilatata; C1qa protein, mouse; complement component C1q; animal; brain injury; complication; disease model; epilepsy; genetics; metabolism; microglia; mouse; pathophysiology; physiology; sleep disorder; sleep stage; thalamus; Animals; Brain Injuries; Complement C1q; Disease Models, Animal; Epilepsy; Mice; Microglia; Sleep Stages; Sleep Wake Disorders; Thalamus
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/244042
作者单位	Neurosciences Graduate Program, University of California, San Francisco, San Francisco, CA 94158, United States; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, United States; Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, United States; Department of Fundamental Neurosciences, University of Lausanne, Lausanne, CH-1005, Switzerland; Annexon Biosciences, South San Francisco, CA 94080, United States; Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, United States; Department of Neuropathology, Amsterdam UMC, University of Amsterdam, Amsterdam, 1105 AZ, Netherlands; Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede, 2103 SW, Netherlands; The Kavli Institute for Fundamental Neuroscience, The Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, United States
推荐引用方式 GB/T 7714	Holden S.S.,Grandi F.C.,Aboubakr O.,et al. Complement factor C1q mediates sleep spindle loss and epileptic spikes after mild brain injury[J],2021,373(6560).
APA	Holden S.S..,Grandi F.C..,Aboubakr O..,Higashikubo B..,Cho F.S..,...&Paz J.T..(2021).Complement factor C1q mediates sleep spindle loss and epileptic spikes after mild brain injury.Science,373(6560).
MLA	Holden S.S.,et al."Complement factor C1q mediates sleep spindle loss and epileptic spikes after mild brain injury".Science 373.6560(2021).