气候变化领域集成服务门户(CCPortal): Amygdala ensembles encode behavioral states

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DOI	10.1126/science.aav8736
	Amygdala ensembles encode behavioral states
	Gründemann J.; Bitterman Y.; Lu T.; Krabbe S.; Grewe B.F.; Schnitzer M.J.; Lüthi A.
发表日期	2019
ISSN	0036-8075
卷号	364 期号:6437
英文摘要	Internal states, including affective or homeostatic states, are important behavioral motivators. The amygdala regulates motivated behaviors, yet how distinct states are represented in amygdala circuits is unknown. By longitudinally imaging neural calcium dynamics in freely moving mice across different environments, we identified opponent changes in activity levels of two major, nonoverlapping populations of basal amygdala principal neurons. This population signature does not report global anxiety but predicts switches between exploratory and nonexploratory, defensive states. Moreover, the amygdala separately processes external stimuli and internal states and broadcasts state information via several output pathways to larger brain networks. Our findings extend the concept of thalamocortical “brain-state” coding to include affective and exploratory states and provide an entry point into the state dependency of brain function and behavior in defined circuits. 2017 © The Authors,
英文关键词	behavior; brain; cell; homeostasis; imaging method; rodent; amygdala; animal cell; animal experiment; animal tissue; anxiety; Article; basal amygdala; behavior change; brain function; brain region; controlled study; defensive behavior; exploratory behavior; male; mouse; nerve cell; nerve cell network; nonhuman; prediction; priority journal; thalamocortical tract; affect; animal; basolateral amygdala; brain depth stimulation; C57BL mouse; fluorescence; functional neuroimaging; maze test; metabolism; nerve tract; physiology; psychology; Mus; calcium; calcium calmodulin dependent protein kinase II; Affect; Animals; Anxiety; Basolateral Nuclear Complex; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Deep Brain Stimulation; Exploratory Behavior; Fluorescence; Functional Neuroimaging; Male; Maze Learning; Mice; Mice, Inbred C57BL; Neural Pathways; Neurons
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/243883
作者单位	Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel, Switzerland; Department of Biomedicine, University of Basel, Klingelbergstrasse 50-70, Basel, Switzerland; Institute of Neuroinformatics, University and ETH Zürich, Winterthurerstrasse 190, Zürich, Switzerland; Department of Electrical Engineering and Information Technology, ETH Zürich, Switzerland; Howard Hughes Medical Institute, CNC Program, James H. Clark Center for Biomedical Engineering and Sciences, Stanford University, Stanford, CA, United States; University of Basel, Basel, 4000, Switzerland
推荐引用方式 GB/T 7714	Gründemann J.,Bitterman Y.,Lu T.,et al. Amygdala ensembles encode behavioral states[J],2019,364(6437).
APA	Gründemann J..,Bitterman Y..,Lu T..,Krabbe S..,Grewe B.F..,...&Lüthi A..(2019).Amygdala ensembles encode behavioral states.Science,364(6437).
MLA	Gründemann J.,et al."Amygdala ensembles encode behavioral states".Science 364.6437(2019).