气候变化领域集成服务门户(CCPortal): Absolute and arbitrary orientation of single-molecule shapes

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DOI	10.1126/science.abd6179
	Absolute and arbitrary orientation of single-molecule shapes
	Gopinath A.; Thachuk C.; Mitskovets A.; Atwater H.A.; Kirkpatrick D.; Rothemund P.W.K.
发表日期	2021
ISSN	0036-8075
卷号	371 期号:6531
英文摘要	DNA origami is a modular platform for the combination of molecular and colloidal components to create optical, electronic, and biological devices. Integration of such nanoscale devices with microfabricated connectors and circuits is challenging: Large numbers of freely diffusing devices must be fixed at desired locations with desired alignment. We present a DNA origami molecule whose energy landscape on lithographic binding sites has a unique maximum. This property enabled device alignment within 3.2° on silica surfaces. Orientation was absolute (all degrees of freedom were specified) and arbitrary (the orientation of every molecule was independently specified). The use of orientation to optimize device performance was shown by aligning fluorescent emission dipoles within microfabricated optical cavities. Large-scale integration was demonstrated with an array of 3456 DNA origami with 12 distinct orientations that indicated the polarization of excitation light. © 2021 American Association for the Advancement of Science. All rights reserved.
英文关键词	nanoparticle; silicon dioxide; silicon nitride; DNA; nanomaterial; DNA; equipment; molecular analysis; performance assessment; Article; atomic force microscopy; binding site; chemical phenomena; controlled study; device alignment; dipole; DNA origami molecule; DNA origami placement; DNA structure; excitation; finite difference time domain simulation; measurement precision; microtechnology; molecule; nanofabrication; physical phenomena; polarization; priority journal; process optimization; simulation; synthesis; thermodynamics; chemistry; conformation; nanotechnology; rotation; Binding Sites; DNA; Nanostructures; Nanotechnology; Nucleic Acid Conformation; Rotation; Silicon Dioxide; Thermodynamics
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/243836
作者单位	Department of Bioengineering, California Institute of Technology, Pasadena, CA 91125, United States; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States; Department of Computing and Mathematical Science, California Institute of Technology, Pasadena, CA 91125, United States; Paul G. Allen School of Computer Science and Engineering, University of Washington, Seattle, WA 98195, United States; Department of Applied Physics and Materials Science, California Institute of Technology, Pasadena, CA 91125, United States; Department of Computer Science, University of British Columbia, Vancouver, BC, Canada; Computation and Neural Systems, California Institute of Technology, Pasadena, CA 91125, United States
推荐引用方式 GB/T 7714	Gopinath A.,Thachuk C.,Mitskovets A.,et al. Absolute and arbitrary orientation of single-molecule shapes[J],2021,371(6531).
APA	Gopinath A.,Thachuk C.,Mitskovets A.,Atwater H.A.,Kirkpatrick D.,&Rothemund P.W.K..(2021).Absolute and arbitrary orientation of single-molecule shapes.Science,371(6531).
MLA	Gopinath A.,et al."Absolute and arbitrary orientation of single-molecule shapes".Science 371.6531(2021).