气候变化领域集成服务门户(CCPortal): C-H bond functionalization in complex organic synthesis

CCPortal

DOI	10.1126/science.1114731
	C-H bond functionalization in complex organic synthesis
	Godula K.; Sames D.
发表日期	2006
ISSN	0036-8075
起始页码	67
结束页码	72
卷号	312 期号:5770
英文摘要	Direct and selective replacement of carbon-hydrogen bonds with new bonds (such as C-C, C-O, and C-N) represents an important and long-standing goal in chemistry. These transformations have broad potential in synthesis because C-H bonds are ubiquitous in organic substances. At the same time, achieving selectivity among many different C-H bonds remains a challenge. Here, we focus on the functionalization of C-H bonds in complex organic substrates catalyzed by transition metal catalysts. We outline the key concepts and approaches aimed at achieving selectivity in complex settings and discuss the impact these reactions have on synthetic planning and strategy in organic synthesis.
英文关键词	Catalysis; Organic compounds; Substrates; Synthesis (chemical); Transition metal compounds; C-H bond functionalization; C-H bonds; Organic substrates; Organic synthesis; Hydrogen bonds; alkyl group; aromatic compound; carbene; carbon; coordination compound; hydrogen; methyl group; organic compound; radical; transition element; carbon; catalysis; chemical bonding; hydrogen; organic compound; substrate; transformation; algorithm; carbon hydrogen bond functionalization; catalysis; catalyst; chemical bond; chemical structure; cross coupling reaction; enantioselectivity; energy; metallation; molecular interaction; priority journal; reaction analysis; review; stoichiometry; structure analysis; synthesis
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/243824
作者单位	Department of Chemistry, Columbia University, 3000 Broadway, New York, NY 10027, United States
推荐引用方式 GB/T 7714	Godula K.,Sames D.. C-H bond functionalization in complex organic synthesis[J],2006,312(5770).
APA	Godula K.,&Sames D..(2006).C-H bond functionalization in complex organic synthesis.Science,312(5770).
MLA	Godula K.,et al."C-H bond functionalization in complex organic synthesis".Science 312.5770(2006).