气候变化领域集成服务门户(CCPortal): Effects of microbiota-directed foods in gnotobiotic animals and undernourished children

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DOI	10.1126/science.aau4732
	Effects of microbiota-directed foods in gnotobiotic animals and undernourished children
	Gehrig J.L.; Venkatesh S.; Chang H.-W.; Hibberd M.C.; Kung V.L.; Cheng J.; Chen R.Y.; Subramanian S.; Cowardin C.A.; Meier M.F.; O’Donnell D.; Talcott M.; Spears L.D.; Semenkovich C.F.; Henrissat B.; Giannone R.J.; Hettich R.L.; Ilkayeva O.; Muehlbauer M.; Newgard C.B.; Sawyer C.; Head R.D.; Rodionov D.A.; Arzamasov A.A.; Leyn S.A.; Osterman A.L.; Hossain M.I.; Islam M.; Choudhury N.; Sarker S.A.; Huq S.; Mahmud I.; Mostafa I.; Mahfuz M.; Barratt M.J.; Ahmed T.; Gordon J.I.
发表日期	2019
ISSN	0036-8075
卷号	365 期号:6449
英文摘要	To examine the contributions of impaired gut microbial community development to childhood undernutrition, we combined metabolomic and proteomic analyses of plasma samples with metagenomic analyses of fecal samples to characterize the biological state of Bangladeshi children with severe acute malnutrition (SAM) as they transitioned, after standard treatment, to moderate acute malnutrition (MAM) with persistent microbiota immaturity. Host and microbial effects of microbiota-directed complementary food (MDCF) prototypes targeting weaning-phase bacterial taxa underrepresented in SAM and MAM microbiota were characterized in gnotobiotic mice and gnotobiotic piglets colonized with age- and growth-discriminatory bacteria. A randomized, double-blind controlled feeding study identified a lead MDCF that changes the abundances of targeted bacteria and increases plasma biomarkers and mediators of growth, bone formation, neurodevelopment, and immune function in children with MAM. © 2019 American Association for the Advancement of Science. All rights reserved.
英文关键词	biological marker; C reactive protein; interleukin 6; plasma protein; biomarker; child; child health; community development; digestive system; food; malnutrition; microorganism; nutrition; plasma; proteomics; sampling; arm circumference; Article; bacterial taxonomy; Bangladesh; child; child growth; clinical effectiveness; community; community assembly; controlled clinical trial; controlled study; cost effectiveness analysis; cultural factor; diet therapy; double blind procedure; feeding; food; food composition; gnotobiotics; health care quality; host microbe interaction; human; immaturity; immune response; immunopathogenesis; immunopathology; infant; intestine flora; longitudinal study; major clinical study; male; malnutrition; mental disease; metabolite; metabolomics; metagenomics; microbiota directed complementary food; mid upper arm circumference; milk; moderate acute malnutrition; mouse; nerve cell differentiation; nonhuman; ossification; piglet; plasma; preschool child; priority journal; proteomics; randomized controlled trial; stunting; sustainable growth; taxonomy; weaning; animal; germfree animal; infant nutrition; metabolism; microbiology; nutritional disorder; Animalia; Bacteria (microorganisms); Mus; Animals; Bangladesh; Blood Proteins; Child Nutrition Disorders; Child, Preschool; Gastrointestinal Microbiome; Germ-Free Life; Host Microbial Interactions; Humans; Infant; Infant Nutritional Physiological Phenomena
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/243794
作者单位	Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, United States; Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63110, United States; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, United States; Division of Comparative Medicine, Washington University, St. Louis, MO 63110, United States; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, United States; Fonction des Macromolécules Biologiques, Centre National de la Recherche Scientifique, Aix-Marseille Université, Marseille Cedex 9, 13288, France; Department of Biological Sciences, King Abdulaziz University, Jeddah, Saudi Arabia; Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37830, United States; Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27710, United...
推荐引用方式 GB/T 7714	Gehrig J.L.,Venkatesh S.,Chang H.-W.,et al. Effects of microbiota-directed foods in gnotobiotic animals and undernourished children[J],2019,365(6449).
APA	Gehrig J.L..,Venkatesh S..,Chang H.-W..,Hibberd M.C..,Kung V.L..,...&Gordon J.I..(2019).Effects of microbiota-directed foods in gnotobiotic animals and undernourished children.Science,365(6449).
MLA	Gehrig J.L.,et al."Effects of microbiota-directed foods in gnotobiotic animals and undernourished children".Science 365.6449(2019).