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DOI	10.1126/science.aau8650
	The NASA twins study: A multidimensional analysis of a year-long human spaceflight
	Garrett-Bakelman F.E.; Darshi M.; Green S.J.; Gur R.C.; Lin L.; Macias B.R.; McKenna M.J.; Meydan C.; Mishra T.; Nasrini J.; Piening B.D.; Rizzardi L.F.; Sharma K.; Siamwala J.H.; Taylor L.; Vitaterna M.H.; Afkarian M.; Afshinnekoo E.; Ahadi S.; Ambati A.; Arya M.; Bezdan D.; Callahan C.M.; Chen S.; Choi A.M.K.; Chlipala G.E.; Contrepois K.; Covington M.; Crucian B.E.; De Vivo I.; Dinges D.F.; Ebert D.J.; Feinberg J.I.; Gandara J.A.; George K.A.; Goutsias J.; Grills G.S.; Hargens A.R.; Heer M.; Hillary R.P.; Hoofnagle A.N.; Hook V.Y.H.; Jenkinson G.; Jiang P.; Keshavarzian A.; Laurie S.S.; Lee-McMullen B.; Lumpkins S.B.; MacKay M.; Maienschein-Cline M.G.; Melnick A.M.; Moore T.M.; Nakahira K.; Patel H.H.; Pietrzyk R.; Rao V.; Saito R.; Salins D.N.; Schilling J.M.; Sears D.D.; Sheridan C.K.; Stenger M.B.; Tryggvadottir R.; Urban A.E.; Vaisar T.; Van Espen B.; Zhang J.; Ziegler M.G.; Zwart S.R.; Charles J.B.; Kundrot C.E.; Scott G.B.I.; Bailey S.M.; Basner M.; Feinberg A.P.; Lee S.M.C.; Mason C.E.; Mignot E.; Rana B.K.; Smith S.M.; Snyder M.P.; Turek F.W.
发表日期	2019
ISSN	0036-8075
卷号	364 期号:6436
英文摘要	To understand the health impact of long-duration spaceflight, one identical twin astronaut was monitored before, during, and after a 1-year mission onboard the International Space Station; his twin served as a genetically matched ground control. Longitudinal assessments identified spaceflight-specific changes, including decreased body mass, telomere elongation, genome instability, carotid artery distension and increased intimamedia thickness, altered ocular structure, transcriptional and metabolic changes, DNA methylation changes in immune and oxidative stress-related pathways, gastrointestinal microbiota alterations, and some cognitive decline postflight. Although average telomere length, global gene expression, and microbiome changes returned to near preflight levels within 6 months after return to Earth, increased numbers of short telomeres were observed and expression of some genes was still disrupted. These multiomic, molecular, physiological, and behavioral datasets provide a valuable roadmap of the putative health risks for future human spaceflight. © 2017 The Authors.
英文关键词	DNA; body mass; DNA; gene; gene expression; genome; health impact; health risk; methylation; microorganism; molecular analysis; oxidative stress; physiology; arterial wall thickness; artery dilatation; Article; body mass; carotid artery; cognitive defect; DNA methylation; environmental factor; gene expression; genomic instability; health care; health hazard; human; immune response; incidence; inflammation; intestine flora; microbiome; osteolysis; oxidative stress; priority journal; sensorimotor function; space flight; steady state; telomere length; adaptation; adaptive immunity; body weight; cosmonaut; diagnostic imaging; DNA damage; government; male; telomere homeostasis; time factor; twins; United States; Adaptation, Physiological; Adaptive Immunity; Astronauts; Body Weight; Carotid Arteries; Carotid Intima-Media Thickness; DNA Damage; DNA Methylation; Gastrointestinal Microbiome; Genomic Instability; Humans; Male; Space Flight; Telomere Homeostasis; Time Factors; United States; United States National Aeronautics and Space Administration
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/243782
作者单位	Weill Cornell Medicine, New York, NY, United States; University of Virginia School of Medicine, Charlottesville, VA, United States; Center for Renal Precision Medicine, University of Texas Health, San Antonio, TX, United States; University of Illinois at Chicago, Chicago, IL, United States; University of Pennsylvania Perelman, School of Medicine, Philadelphia, PA, United States; Stanford University School of Medicine, Palo Alto, CA, United States; KBRwyle, Houston, TX, United States; Colorado State University, Fort Collins, CO, United States; Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, New York, NY, United States; Johns Hopkins University, Baltimore, MD, United States; University of California, San Diego, San Diego, CA, United States; Northwestern University, Evanston, IL, United States; University of California, Davis, Davis, CA, United States; National Aeronautics and Space Administration (NASA), Houston, TX, United States; Harvard T.H. Chan School of Public Health, Boston, M...
推荐引用方式 GB/T 7714	Garrett-Bakelman F.E.,Darshi M.,Green S.J.,et al. The NASA twins study: A multidimensional analysis of a year-long human spaceflight[J],2019,364(6436).
APA	Garrett-Bakelman F.E..,Darshi M..,Green S.J..,Gur R.C..,Lin L..,...&Turek F.W..(2019).The NASA twins study: A multidimensional analysis of a year-long human spaceflight.Science,364(6436).
MLA	Garrett-Bakelman F.E.,et al."The NASA twins study: A multidimensional analysis of a year-long human spaceflight".Science 364.6436(2019).