气候变化领域集成服务门户(CCPortal): Chemical dynamics in proteins: The photoisomerization of retinal in bacteriorhodopsin

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DOI	10.1126/science.279.5358.1886
	Chemical dynamics in proteins: The photoisomerization of retinal in bacteriorhodopsin
	Gai F.; Hasson K.C.; McDonald J.C.; Anfinrud P.A.
发表日期	1998
ISSN	0036-8075
起始页码	1886
结束页码	1891
卷号	279 期号:5358
英文摘要	Chemical dynamics in proteins are discussed with bacteriorhodopsin serving as a model system. Ultrafast time resolved methods used to probe the chemical dynamics of retinal photoisomerization in bacteriorhodops are discussed, along with future prospects for ultrafast time-resolved crystallography. The photoisomerization of retinal in bacteriorhodopsin is far more selective and efficient than in solution the origins of which are discussed in the context of a three-state model for the photoisomerization reaction coordinate. The chemical dynamics are complex, with the excited relaxation exhibiting a multiexponential decay with well-defined rate constants. Possible origins for the two major components are also discussed.
英文关键词	bacteriorhodopsin; retinal; schiff base; absorption spectroscopy; article; isomerism; molecular dynamics; photoreactivity; priority journal; Bacteriorhodopsins; Halobacterium salinarum; Isomerism; Kinetics; Light; Models, Chemical; Protein Conformation; Retinaldehyde; Spectrum Analysis; Thermodynamics
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/243764
作者单位	Dept. of Chem. and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, United States; Los Alamos National Laboratory, CST-4, MS J586, Los Alamos, NM 87545, United States; Magnetic Imaging Technologies, 2500 Meridian Parkway, Durham, NC 27713, United States
推荐引用方式 GB/T 7714	Gai F.,Hasson K.C.,McDonald J.C.,et al. Chemical dynamics in proteins: The photoisomerization of retinal in bacteriorhodopsin[J],1998,279(5358).
APA	Gai F.,Hasson K.C.,McDonald J.C.,&Anfinrud P.A..(1998).Chemical dynamics in proteins: The photoisomerization of retinal in bacteriorhodopsin.Science,279(5358).
MLA	Gai F.,et al."Chemical dynamics in proteins: The photoisomerization of retinal in bacteriorhodopsin".Science 279.5358(1998).