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DOI	10.1126/science.aax5440
	Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep
	Fultz N.E.; Bonmassar G.; Setsompop K.; Stickgold R.A.; Rosen B.R.; Polimeni J.R.; Lewis L.D.
发表日期	2019
ISSN	0036-8075
起始页码	628
结束页码	631
卷号	366 期号:6465
英文摘要	Sleep is essential for both cognition and maintenance of healthy brain function. Slow waves in neural activity contribute to memory consolidation, whereas cerebrospinal fluid (CSF) clears metabolic waste products from the brain. Whether these two processes are related is not known. We used accelerated neuroimaging to measure physiological and neural dynamics in the human brain. We discovered a coherent pattern of oscillating electrophysiological, hemodynamic, and CSF dynamics that appears during non–rapid eye movement sleep. Neural slow waves are followed by hemodynamic oscillations, which in turn are coupled to CSF flow. These results demonstrate that the sleeping brain exhibits waves of CSF flow on a macroscopic scale, and these CSF dynamics are interlinked with neural and hemodynamic rhythms. © 2019 American Association for the Advancement of Science. All rights reserved.
英文关键词	cognition; electrical method; fluid; hemoglobin; oscillation; sleep; article; brain; cerebrospinal fluid; cerebrospinal fluid flow; hemodynamics; human; human experiment; neuroimaging; nonREM sleep; oscillation; rhythm; adult; brain circulation; cerebrospinal fluid; delta rhythm; electroencephalogram; electroencephalography; female; hemodynamics; male; nuclear magnetic resonance imaging; physiology; sleep; vascularization; young adult; Adult; Brain; Brain Waves; Cerebrospinal Fluid; Cerebrovascular Circulation; Delta Rhythm; Electroencephalography; Female; Hemodynamics; Humans; Magnetic Resonance Imaging; Male; Sleep; Young Adult
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/243755
作者单位	Department of Biomedical Engineering, Boston University, Boston, MA 02215, United States; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA 02129, United States; Department of Radiology, Harvard Medical School, Boston, MA 02115, United States; Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA 02215, United States; Department of Psychiatry, Harvard Medical School, Boston, MA 02115, United States
推荐引用方式 GB/T 7714	Fultz N.E.,Bonmassar G.,Setsompop K.,et al. Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep[J],2019,366(6465).
APA	Fultz N.E..,Bonmassar G..,Setsompop K..,Stickgold R.A..,Rosen B.R..,...&Lewis L.D..(2019).Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep.Science,366(6465).
MLA	Fultz N.E.,et al."Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep".Science 366.6465(2019).