气候变化领域集成服务门户(CCPortal): Senescence in immunity against helminth parasites predicts adult mortality in a wild mammal

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DOI	10.1126/science.aaw5822
	Senescence in immunity against helminth parasites predicts adult mortality in a wild mammal
	Froy H.; Sparks A.M.; Watt K.; Sinclair R.; Bach F.; Pilkington J.G.; Pemberton J.M.; McNeilly T.N.; Nussey D.H.
发表日期	2019
ISSN	0036-8075
起始页码	1296
结束页码	1298
卷号	365 期号:6459
英文摘要	Our understanding of the deterioration in immune function in old age-immunosenescence- derives principally from studies of modern human populations and laboratory animals. The generality and significance of this process for systems experiencing complex, natural infections and environmental challenges are unknown. Here, we show that late-life declines in an important immune marker of resistance to helminth parasites in wild Soay sheep predict overwinter mortality. We found senescence in circulating antibody levels against a highly prevalent nematode worm, which was associated with reduced adult survival probability, independent of changes in body weight. These findings establish a role for immunosenescence in the ecology and evolution of natural populations. © 2019 American Association for the Advancement of Science. All rights reserved.
英文关键词	adult; immune response; immunity; laboratory method; mammal; mortality; overwintering; parasite; prediction; senescence; wild population; adult; animal experiment; animal model; article; body weight change; ecology; female; immunosenescence; male; mortality; natural population; nematode; nonhuman; sheep; survival rate; aging; animal; animal parasitosis; blood; body weight; disease resistance; immunology; parasite egg count; parasite load; parasitology; Scotland; sheep; sheep disease; statistical model; survival analysis; Animalia; Mammalia; Ovis aries; Vermes; helminth antibody; immunoglobulin G; Aging; Animals; Antibodies, Helminth; Body Weight; Disease Resistance; Female; Helminthiasis, Animal; Immunoglobulin G; Immunosenescence; Linear Models; Male; Parasite Egg Count; Parasite Load; Scotland; Sheep; Sheep Diseases; Survival Analysis
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/243745
作者单位	Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, United Kingdom; Centre for Biodiversity Dynamics, Norwegian University of Science and Technology, Trondheim, Norway; School of Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom; Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom; Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, United Kingdom
推荐引用方式 GB/T 7714	Froy H.,Sparks A.M.,Watt K.,et al. Senescence in immunity against helminth parasites predicts adult mortality in a wild mammal[J],2019,365(6459).
APA	Froy H..,Sparks A.M..,Watt K..,Sinclair R..,Bach F..,...&Nussey D.H..(2019).Senescence in immunity against helminth parasites predicts adult mortality in a wild mammal.Science,365(6459).
MLA	Froy H.,et al."Senescence in immunity against helminth parasites predicts adult mortality in a wild mammal".Science 365.6459(2019).