气候变化领域集成服务门户(CCPortal): Locally coordinated synaptic plasticity of visual cortex neurons in vivo

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DOI	10.1126/science.aao0862
	Locally coordinated synaptic plasticity of visual cortex neurons in vivo
	El-Boustani S.; Ip J.P.K.; Breton-Provencher V.; Knott G.W.; Okuno H.; Bito H.; Sur M.
发表日期	2018
ISSN	0036-8075
起始页码	1349
结束页码	1354
卷号	360 期号:6395
英文摘要	Plasticity of cortical responses in vivo involves activity-dependent changes at synapses, but the manner in which different forms of synaptic plasticity act together to create functional changes in neurons remains unknown. We found that spike timing–induced receptive field plasticity of visual cortex neurons in mice is anchored by increases in the synaptic strength of identified spines. This is accompanied by a decrease in the strength of adjacent spines on a slower time scale. The locally coordinated potentiation and depression of spines involves prominent AMPA receptor redistribution via targeted expression of the immediate early gene product Arc. Hebbian strengthening of activated synapses and heterosynaptic weakening of adjacent synapses thus cooperatively orchestrate cell-wide plasticity of functional neuronal responses. © 2017 The Authors.
英文关键词	AMPA receptor; activity regulated cytoskeletal-associated protein; AMPA receptor; calcium calmodulin dependent protein kinase II; cytoskeleton protein; nerve protein; functional role; gene expression; laboratory method; neurology; plasticity; rodent; visual analysis; animal cell; Article; controlled study; dendritic spine; gene product; long term potentiation; mouse; nerve cell plasticity; nonhuman; priority journal; protein localization; receptive field; spike; visual cortex; animal; C57BL mouse; cytology; electroporation; gene knockdown; genetics; HEK293 cell line; human; long term depression; metabolism; nerve cell; nerve cell plasticity; physiology; synaptic transmission; transgenic mouse; visual cortex; Mus; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cytoskeletal Proteins; Dendritic Spines; Electroporation; Gene Knockdown Techniques; HEK293 Cells; Humans; Long-Term Potentiation; Long-Term Synaptic Depression; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; Neuronal Plasticity; Neurons; Receptors, AMPA; Synaptic Transmission; Visual Cortex
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/243607
作者单位	Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, United States; Bio Electron Microscopy Laboratory, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, 1015, Switzerland; Medical Innovation Center, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, 606-8507, Japan; Department of Neurochemistry, Graduate School of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-0033, Japan; Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, 1015, Switzerland; Department of Biochemistry and Molecular Biology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan
推荐引用方式 GB/T 7714	El-Boustani S.,Ip J.P.K.,Breton-Provencher V.,et al. Locally coordinated synaptic plasticity of visual cortex neurons in vivo[J],2018,360(6395).
APA	El-Boustani S..,Ip J.P.K..,Breton-Provencher V..,Knott G.W..,Okuno H..,...&Sur M..(2018).Locally coordinated synaptic plasticity of visual cortex neurons in vivo.Science,360(6395).
MLA	El-Boustani S.,et al."Locally coordinated synaptic plasticity of visual cortex neurons in vivo".Science 360.6395(2018).