气候变化领域集成服务门户(CCPortal): Homer1a drives homeostatic scaling-down of excitatory synapses during sleep

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DOI	10.1126/science.aai8355
	Homer1a drives homeostatic scaling-down of excitatory synapses during sleep
	Diering G.H.; Nirujogi R.S.; Roth R.H.; Worley P.F.; Pandey A.; Huganir R.L.
发表日期	2017
ISSN	0036-8075
起始页码	511
结束页码	515
卷号	355 期号:6324
英文摘要	Sleep is an essential process that supports learning and memory by acting on synapses through poorly understood molecular mechanisms. Using biochemistry, proteomics, and imaging in mice, we find that during sleep, synapses undergo widespread alterations in composition and signaling, including weakening of synapses through removal and dephosphorylation of synaptic AMPA-type glutamate receptors. These changes are driven by the immediate early gene Homer1a and signaling from group I metabotropic glutamate receptors mGluR1/5. Homer1a serves as a molecular integrator of arousal and sleep need via the wake- and sleep-promoting neuromodulators, noradrenaline and adenosine, respectively. Our data suggest that homeostatic scaling-down, a global form of synaptic plasticity, is active during sleep to remodel synapses and participates in the consolidation of contextual memory. © 2017, American Association for the Advancement of Science. All rights reserved.
英文关键词	adenosine; alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid; chlorpheniramine maleate plus phenylephrine; glutamate receptor; metabotropic receptor; noradrenalin; protein homer 1a; adenosine; Grm5 protein, mouse; homer scaffolding protein; Homer1 protein, mouse; metabotropic glutamate receptor type 1; metabotropic receptor; metabotropic receptor 5; noradrenalin; biochemistry; chemoreception; gene expression; homeostasis; imaging method; learning; memory; nervous system; neurology; proteomics; rodent; sleep; animal experiment; arousal; Article; biochemistry; cell fractionation; dephosphorylation; electroconvulsive therapy; firing rate; forebrain; gene expression; imaging; memory consolidation; mouse; nerve cell; nerve cell plasticity; nonhuman; phenotype; postsynaptic density; primary motor cortex; priority journal; proteomics; pyramidal nerve cell; signal noise ratio; sleep; sleep deprivation; synapse; synaptosome; wakefulness; animal; cell count; cell culture; cognition; cytology; drug effects; genetics; homeostasis; learning; metabolism; physiology; rat; sleep; Sprague Dawley rat; synapse; ultrastructure; Mus; Adenosine; Animals; Cell Count; Cells, Cultured; Cognition; Homeostasis; Homer Scaffolding Proteins; Learning; Mice; Neurons; Norepinephrine; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Sleep; Synapses; Wakefulness
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/243540
作者单位	Solomon Snyder Department of Neuroscience, Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD, United States; Department of Biological Chemistry, Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, United States
推荐引用方式 GB/T 7714	Diering G.H.,Nirujogi R.S.,Roth R.H.,et al. Homer1a drives homeostatic scaling-down of excitatory synapses during sleep[J],2017,355(6324).
APA	Diering G.H.,Nirujogi R.S.,Roth R.H.,Worley P.F.,Pandey A.,&Huganir R.L..(2017).Homer1a drives homeostatic scaling-down of excitatory synapses during sleep.Science,355(6324).
MLA	Diering G.H.,et al."Homer1a drives homeostatic scaling-down of excitatory synapses during sleep".Science 355.6324(2017).