气候变化领域集成服务门户(CCPortal): Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques

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DOI	10.1126/science.abc5343
	Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques
	Deng W.; Bao L.; Liu J.; Xiao C.; Liu J.; Xue J.; Lv Q.; Qi F.; Gao H.; Yu P.; Xu Y.; Qu Y.; Li F.; Xiang Z.; Yu H.; Gong S.; Liu M.; Wang G.; Wang S.; Song Z.; Liu Y.; Zhao W.; Han Y.; Zhao L.; Liu X.; Wei Q.; Qin C.
发表日期	2020
ISSN	0036-8075
起始页码	818
结束页码	823
卷号	369 期号:6505
英文摘要	Coronavirus disease 2019 (COVID-19), which is caused by infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic. It is unclear whether convalescing patients have a risk of reinfection. We generated a rhesus macaque model of SARS-CoV-2 infection that was characterized by interstitial pneumonia and systemic viral dissemination mainly in the respiratory and gastrointestinal tracts. Rhesus macaques reinfected with the identical SARS-CoV-2 strain during the early recovery phase of the initial SARS-CoV-2 infection did not show detectable viral dissemination, clinical manifestations of viral disease, or histopathological changes. Comparing the humoral and cellular immunity between primary infection and rechallenge revealed notably enhanced neutralizing antibody and immune responses. Our results suggest that primary SARS-CoV-2 exposure protects against subsequent reinfection in rhesus macaques. © 2020 American Association for the Advancement of Science. All rights reserved.
英文关键词	coronavirus spike glycoprotein; neutralizing antibody; virus antibody; antibody; cell component; gastroenteritis; histopathology; immune response; infectious disease; primate; respiratory disease; viral disease; adult; animal cell; animal experiment; animal model; animal tissue; Article; body weight loss; cellular immunity; clinical feature; controlled study; coronavirus disease 2019; histopathology; humoral immunity; immune response; infection risk; interstitial pneumonia; monkey model; nonhuman; primary infection; priority journal; rectal temperature; reinfection; rhesus monkey; Severe acute respiratory syndrome coronavirus 2; virus load; virus replication; anal canal; animal; B lymphocyte subpopulation; Betacoronavirus; blood; Coronavirus infection; diagnostic imaging; disease model; immunology; interstitial lung disease; isolation and purification; lung; nasopharynx; pandemic; pathology; pathophysiology; physiology; recurrent disease; rhesus monkey; T lymphocyte subpopulation; virology; virus pneumonia; Coronavirus; Macaca mulatta; SARS coronavirus; Anal Canal; Animals; Antibodies, Neutralizing; Antibodies, Viral; B-Lymphocyte Subsets; Betacoronavirus; Coronavirus Infections; Disease Models, Animal; Host Microbial Interactions; Immunity, Cellular; Immunity, Humoral; Lung; Lung Diseases, Interstitial; Macaca mulatta; Nasopharynx; Pandemics; Pneumonia, Viral; Recurrence; T-Lymphocyte Subsets; Viral Load; Virus Replication
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/243512
作者单位	Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, NHC Key Laboratory of Human Disease Comparative Medicine, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, China; Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
推荐引用方式 GB/T 7714	Deng W.,Bao L.,Liu J.,et al. Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques[J],2020,369(6505).
APA	Deng W..,Bao L..,Liu J..,Xiao C..,Liu J..,...&Qin C..(2020).Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques.Science,369(6505).
MLA	Deng W.,et al."Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques".Science 369.6505(2020).