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DOI	10.1126/science.1060937
	Expectation and dopamine release: Mechanism of the placebo effect in Parkinson's disease
	De la Fuente-Fernández R.; Ruth T.J.; Sossi V.; Schulzer M.; Calne D.B.; Stoessl A.J.
发表日期	2001
ISSN	0036-8075
起始页码	1164
结束页码	1166
卷号	293 期号:5532
英文摘要	The power of placebos has long been recognized for improving numerous medical conditions such as Parkinson's disease (PD). Little is known, however, about the mechanism underlying the placebo effect. Using the ability of endogenous dopamine to compete for [11C]raclopride binding as measured by positron emission tomography, we provide in vivo evidence for substantial release of endogenous dopamine in the striatum of PD patients in response to placebo. Our findings indicate that the placebo effect in PD is powerful and is mediated through activation of the damaged nigrostriatal dopamine system.
英文关键词	Diseases; Placebos; Biomedical engineering; carbon 11; dopamine; placebo; raclopride; disease control; article; clinical article; controlled study; corpus striatum; dopamine release; drug receptor binding; expectation; human; in vivo study; nigroneostriatal system; Parkinson disease; positron emission tomography; priority journal; Aged; Antiparkinson Agents; Apomorphine; Corpus Striatum; Dopamine; Female; Humans; Male; Middle Aged; Parkinson Disease; Placebo Effect; Placebos; Raclopride; Synapses; Tomography, Emission-Computed
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/243480
作者单位	Neurodegenerative Disorders Centre, University of British Columbia, Vancouver, BC V6T 2B5, Canada
推荐引用方式 GB/T 7714	De la Fuente-Fernández R.,Ruth T.J.,Sossi V.,et al. Expectation and dopamine release: Mechanism of the placebo effect in Parkinson's disease[J],2001,293(5532).
APA	De la Fuente-Fernández R.,Ruth T.J.,Sossi V.,Schulzer M.,Calne D.B.,&Stoessl A.J..(2001).Expectation and dopamine release: Mechanism of the placebo effect in Parkinson's disease.Science,293(5532).
MLA	De la Fuente-Fernández R.,et al."Expectation and dopamine release: Mechanism of the placebo effect in Parkinson's disease".Science 293.5532(2001).