气候变化领域集成服务门户(CCPortal): Preventing type 1 diabetes in childhood

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DOI	10.1126/science.abi4742
	Preventing type 1 diabetes in childhood
	Dayan C.M.; Besser R.E.J.; Oram R.A.; Hagopian W.; Vatish M.; Bendor-Samuel O.; Snape M.D.; Todd J.A.
发表日期	2021
ISSN	0036-8075
起始页码	506
结束页码	510
卷号	373 期号:6554
英文摘要	Type 1 diabetes (T1D) is an autoimmune disease in which the insulin-producing b cells of the pancreas are destroyed by T lymphocytes. Recent studies have demonstrated that monitoring for pancreatic islet autoantibodies, combined with genetic risk assessment, can identify most children who will develop T1D when they still have sufficient b cell function to control glucose concentrations without the need for insulin. In addition, there has been recent success in secondary prevention using immunotherapy to delay the progression of preclinical disease, and primary prevention approaches to inhibiting the initiating autoimmune process have entered large-scale clinical trials. By changing the focus of T1D management from late diagnosis and insulin replacement to early diagnosis and b cell preservation, we can anticipate a future without the need for daily insulin injections for children with T1D. © 2021, American Association for the Advancement of Science
英文关键词	cell; child health; concentration (composition); diabetes; immune response; autoantibody; biological marker; insulin; pancreas islet cell antibody; blood; child; disease exacerbation; early diagnosis; genetic predisposition; genetic screening; genetics; human; immunology; insulin dependent diabetes mellitus; pancreas islet; pancreas islet beta cell; physiology; primary prevention; secondary prevention; Autoantibodies; Biomarkers; Child; Diabetes Mellitus, Type 1; Disease Progression; Early Diagnosis; Genetic Predisposition to Disease; Genetic Testing; Humans; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Primary Prevention; Secondary Prevention
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/243473
作者单位	Wellcome Centre for Human Genetics, Nuffield Department of Medicine, National Institute for Health Research (NIHR), Biomedical Research Centre, University of Oxford, Oxford, United Kingdom; Cardiff University School of Medicine, Cardiff, United Kingdom; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, United Kingdom; Pacific Northwest Research Institute, Seattle, WA, United States; Department of Women’s and Reproductive Health, University of Oxford, Oxford, United Kingdom; Department of Paediatrics, University of Oxford, Oxford, United Kingdom; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford NIHR Biomedical Research Centre, Oxford, United Kingdom
推荐引用方式 GB/T 7714	Dayan C.M.,Besser R.E.J.,Oram R.A.,et al. Preventing type 1 diabetes in childhood[J],2021,373(6554).
APA	Dayan C.M..,Besser R.E.J..,Oram R.A..,Hagopian W..,Vatish M..,...&Todd J.A..(2021).Preventing type 1 diabetes in childhood.Science,373(6554).
MLA	Dayan C.M.,et al."Preventing type 1 diabetes in childhood".Science 373.6554(2021).