气候变化领域集成服务门户(CCPortal): Cellular transcriptomics reveals evolutionary identities of songbird vocal circuits

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DOI	10.1126/science.abd9704
	Cellular transcriptomics reveals evolutionary identities of songbird vocal circuits
	Colquitt B.M.; Merullo D.P.; Konopka G.; Roberts T.F.; Brainard M.S.
发表日期	2021
ISSN	0036-8075
卷号	371 期号:6530
英文摘要	Birds display advanced behaviors, including vocal learning and problem-solving, yet lack a layered neocortex, a structure associated with complex behavior in mammals. To determine whether these behavioral similarities result from shared or distinct neural circuits, we used single-cell RNA sequencing to characterize the neuronal repertoire of the songbird song motor pathway. Glutamatergic vocal neurons had considerable transcriptional similarity to neocortical projection neurons; however, they displayed regulatory gene expression patterns more closely related to neurons in the ventral pallium. Moreover, while g-aminobutyric acid-releasing neurons in this pathway appeared homologous to those in mammals and other amniotes, the most abundant avian class is largely absent in the neocortex. These data suggest that songbird vocal circuits and the mammalian neocortex have distinct developmental origins yet contain transcriptionally similar neurons. Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works
英文关键词	4 aminobutyric acid; transcription factor; 4 aminobutyric acid; glutamic acid; transcriptome; gene expression; genetic analysis; nervous system; neurology; RNA; song; songbird; vocalization; adult; amygdala; animal behavior; animal cell; Article; avian evolution; Bengalese finch; brain cortex; connectome; dorsal ventricular ridge; fluorescence in situ hybridization; GABAergic transmission; gene expression; gene expression profiling; glutamatergic transmission; male; mammal; neocortex; nerve excitability; nerve projection; nonhuman; olfactory bulb; pyriform cortex; reptile; single cell RNA seq; songbird; species comparison; species difference; Taeniopygia guttata; transcriptomics; turtle; vocalization; animal; brain; cytology; evolution; finch; gene expression regulation; genetics; metabolism; neocortex; nerve cell; nerve tract; physiology; single cell analysis; vocalization; Amniota; Mammalia; Passeri; Animals; Biological Evolution; Brain; Finches; gamma-Aminobutyric Acid; Gene Expression Profiling; Gene Expression Regulation; Glutamic Acid; Male; Mammals; Neocortex; Neural Pathways; Neurons; Single-Cell Analysis; Transcriptome; Vocalization, Animal
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/243372
作者单位	Howard Hughes Medical Institute, Chevy Chase, MD 20815, United States; Departments of Physiology and Psychiatry, University of California-San Francisco, San Francisco, CA 94158, United States; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States
推荐引用方式 GB/T 7714	Colquitt B.M.,Merullo D.P.,Konopka G.,et al. Cellular transcriptomics reveals evolutionary identities of songbird vocal circuits[J],2021,371(6530).
APA	Colquitt B.M.,Merullo D.P.,Konopka G.,Roberts T.F.,&Brainard M.S..(2021).Cellular transcriptomics reveals evolutionary identities of songbird vocal circuits.Science,371(6530).
MLA	Colquitt B.M.,et al."Cellular transcriptomics reveals evolutionary identities of songbird vocal circuits".Science 371.6530(2021).