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| DOI | 10.1126/science.aag0804 |
| Industrial biomanufacturing: The future of chemical production | |
| Clomburg J.M.; Crumbley A.M.; Gonzalez R. | |
| 发表日期 | 2017 |
| ISSN | 0036-8075 |
| 卷号 | 355期号:6320 |
| 英文摘要 | The current model for industrial chemical manufacturing employs large-scale megafacilities that benefit from economies of unit scale. However, this strategy faces environmental, geographical, political, and economic challenges associated with energy and manufacturing demands.We review how exploiting biological processes for manufacturing (i.e., industrial biomanufacturing) addresses these concerns while also supporting and benefiting from economies of unit number. Key to this approach is the inherent small scale and capital efficiency of bioprocesses and the ability of engineered biocatalysts to produce designer products at high carbon and energy efficiency with adjustable output, at high selectivity, and under mild process conditions. The biological conversion of single-carbon compounds represents a test bed to establish this paradigm, enabling rapid, mobile, and widespread deployment, access to remote and distributed resources, and adaptation to new and changing markets. © 2016 by the American Association for the Advancement of Science; all rights reserved. |
| 英文关键词 | industrial chemical; biofuel; enzyme; methane; biological production; catalyst; chemical industry; cost-benefit analysis; energy efficiency; industrial enterprise; manufacturing; resource development; alcohol production; automation; biocatalyst; bioprocess; biotechnological production; biotechnology; biotransformation; economic model; energy cost; energy yield; geographic mapping; industrial production; manufacturing industry; metabolic engineering; nonhuman; oil industry; priority journal; process optimization; Review; bioengineering; chemical industry; chemistry; forecasting; metabolism; procedures; trends; Bioengineering; Biofuels; Chemical Industry; Enzymes; Forecasting; Metabolic Networks and Pathways; Methane |
| 语种 | 英语 |
| 来源期刊 | Science
 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/243351 |
| 作者单位 | Department of Chemical and Biomolecular Engineering, Rice University, Houston, TX, United States; Department of Bioengineering, Rice University, Houston, TX, United States |
| 推荐引用方式 GB/T 7714 | Clomburg J.M.,Crumbley A.M.,Gonzalez R.. Industrial biomanufacturing: The future of chemical production[J],2017,355(6320). |
| APA | Clomburg J.M.,Crumbley A.M.,&Gonzalez R..(2017).Industrial biomanufacturing: The future of chemical production.Science,355(6320). |
| MLA | Clomburg J.M.,et al."Industrial biomanufacturing: The future of chemical production".Science 355.6320(2017). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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