气候变化领域集成服务门户(CCPortal): Pcdhαc2 is required for axonal tiling and assembly of serotonergic circuitries in mice

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DOI	10.1126/science.aal3231
	Pcdhαc2 is required for axonal tiling and assembly of serotonergic circuitries in mice
	Chen W.V.; Nwakeze C.L.; Denny C.A.; O'Keeffe S.; Rieger M.A.; Mountoufaris G.; Kirner A.; Dougherty J.D.; Hen R.; Wu Q.; Maniatis T.
发表日期	2017
ISSN	0036-8075
起始页码	406
结束页码	411
卷号	356 期号:6336
英文摘要	Serotonergic neurons project their axons pervasively throughout the brain and innervate various target fields in a space-filling manner, leading to tiled arrangements of their axon terminals to allow optimal allocation of serotonin among target neurons. Here we show that conditional deletion of the mouse protocadherin α (Pcdhα) gene cluster in serotonergic neurons disrupts local axonal tiling and global assembly of serotonergic circuitries and results in depression-like behaviors. Genetic dissection and expression profiling revealed that this role is specifically mediated by Pcdhαc2, which is the only Pcdhα isoform expressed in serotonergic neurons. We conclude that, in contrast to neurite self-avoidance, which requires single-cell identity mediated by Pcdh diversity, a single cell-type identity mediated by the common C-type Pcdh isoform is required for axonal tiling and assembly of serotonergic circuitries. Copyright © 2016 by the American Association for the Advancement of Science; all rights reserved.
英文关键词	cadherin; protocadherin alpha c2; unclassified drug; cadherin; Pcdhalphac2 protein, mouse; serotonin; cells and cell components; gene; gene expression; genetic analysis; protein; rodent; animal experiment; anterior commissure; Article; axon; controlled study; dentate gyrus; gene cluster; gene expression; hippocampus; mouse; nerve ending; nervous system development; nonhuman; priority journal; protein function; protein structure; serotoninergic nerve cell; signal transduction; stratum lacunosum moleculare; stratum radiatum; animal; depression; gene deletion; genetics; limbic system; metabolism; multigene family; mutant mouse strain; pathology; physiology; serotoninergic nerve cell; Mus; Animals; Axons; Cadherins; Depression; Gene Deletion; Limbic System; Mice; Mice, Mutant Strains; Multigene Family; Serotonergic Neurons; Serotonin
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/243304
作者单位	Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, United States; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, United States; Department of Psychiatry, Columbia University, New York, NY 10032, United States; Division of Integrative Neuroscience, Research Foundation for Mental Hygiene, New York, NY 10032, United States; Departments of Genetics and Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, United States; Departments of Neuroscience and Pharmacology, Columbia University, New York, NY 10032, United States; Center for Comparative Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China; Kallyope, New York, NY 10016, United States
推荐引用方式 GB/T 7714	Chen W.V.,Nwakeze C.L.,Denny C.A.,et al. Pcdhαc2 is required for axonal tiling and assembly of serotonergic circuitries in mice[J],2017,356(6336).
APA	Chen W.V..,Nwakeze C.L..,Denny C.A..,O'Keeffe S..,Rieger M.A..,...&Maniatis T..(2017).Pcdhαc2 is required for axonal tiling and assembly of serotonergic circuitries in mice.Science,356(6336).
MLA	Chen W.V.,et al."Pcdhαc2 is required for axonal tiling and assembly of serotonergic circuitries in mice".Science 356.6336(2017).