气候变化领域集成服务门户(CCPortal): A major genome region underlying artemisinin resistance in malaria

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DOI	10.1126/science.1215966
	A major genome region underlying artemisinin resistance in malaria
	Cheeseman I.H.; Miller B.A.; Nair S.; Nkhoma S.; Tan A.; Tan J.C.; Al Saai S.; Phyo A.P.; Ler Moo C.; Lwin K.M.; McGready R.; Ashley E.; Imwong M.; Stepniewska K.; Yi P.; Dondorp A.M.; Mayxay M.; Newton P.N.; White N.J.; Nosten F.; Ferdig M.T.; Anderson T.J.C.
发表日期	2012
ISSN	0036-8075
起始页码	79
结束页码	82
卷号	335 期号:6077
英文摘要	Evolving resistance to artemisinin-based compounds threatens to derail attempts to control malaria. Resistance has been confirmed in western Cambodia and has recently emerged in western Thailand, but is absent from neighboring Laos. Artemisinin resistance results in reduced parasite clearance rates (CRs) after treatment. We used a two-phase strategy to identify genome region(s) underlying this ongoing selective event. Geographical differentiation and haplotype structure at 6969 polymorphic single-nucleotide polymorphisms (SNPs) in 91 parasites from Cambodia, Thailand, and Laos identified 33 genome regions under strong selection. We screened SNPs and microsatellites within these regions in 715 parasites from Thailand, identifying a selective sweep on chromosome 13 that shows strong association (P = 10-6 to 10 -12) with slow CRs, illustrating the efficacy of targeted association for identifying the genetic basis of adaptive traits.
英文关键词	artemisinin; antimalarial agent; artemisinin; artemisinin derivative; microsatellite DNA; protozoal protein; biocontrol agent; chromosome; genetic marker; genome; herb; malaria; parasite resistance; polymorphism; antimalarial drug resistance; article; Cambodia; chromosome 13; gene frequency; genetic association; genetic screening; genetic variability; genotype; geographic distribution; haplotype; human; Laos; major clinical study; malaria; malaria falciparum; nonhuman; Plasmodium falciparum; priority journal; single nucleotide polymorphism; Thailand; comparative study; copy number variation; drug effect; drug resistance; genetic selection; genetics; genome; malaria falciparum; parasitology; Plasmodium falciparum; Cambodia; Laos; Thailand; Antimalarials; Artemisinins; Cambodia; DNA Copy Number Variations; Drug Resistance; Gene Frequency; Genetic Association Studies; Genome, Protozoan; Haplotypes; Humans; Laos; Malaria, Falciparum; Microsatellite Repeats; Plasmodium falciparum; Polymorphism, Single Nucleotide; Protozoan Proteins; Selection, Genetic; Thailand
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/243285
作者单位	Texas Biomedical Research Institute, San Antonio, TX 78245, United States; Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, United States; Shoklo Malaria Research Unit, Mae Sot, Tak, Thailand; Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Tropical Medicine, Churchill Hospital, Oxford, United Kingdom; Wellcome Trust-Mahosot Hospital-Oxford Tropical Medicine Research Collaboration, Mahosot Hospital, Vientiane, Laos; Worldwide Antimalarial Resistance Network, Oxford, United Kingdom; National Center for Parasitology, Entomology, and Malaria Control, Phnom Penh, Cambodia
推荐引用方式 GB/T 7714	Cheeseman I.H.,Miller B.A.,Nair S.,et al. A major genome region underlying artemisinin resistance in malaria[J],2012,335(6077).
APA	Cheeseman I.H..,Miller B.A..,Nair S..,Nkhoma S..,Tan A..,...&Anderson T.J.C..(2012).A major genome region underlying artemisinin resistance in malaria.Science,335(6077).
MLA	Cheeseman I.H.,et al."A major genome region underlying artemisinin resistance in malaria".Science 335.6077(2012).