气候变化领域集成服务门户(CCPortal): A human cell atlas of fetal gene expression

CCPortal

DOI	10.1126/science.aba7721
	A human cell atlas of fetal gene expression
	Cao J.; O’Day D.R.; Pliner H.A.; Kingsley P.D.; Deng M.; Daza R.M.; Zager M.A.; Aldinger K.A.; Blecher-Gonen R.; Zhang F.; Spielmann M.; Palis J.; Doherty D.; Steemers F.J.; Glass I.A.; Trapnell C.; Shendure J.
发表日期	2020
ISSN	0036-8075
卷号	370 期号:6518
英文摘要	The gene expression program underlying the specification of human cell types is of fundamental interest. We generated human cell atlases of gene expression and chromatin accessibility in fetal tissues. For gene expression, we applied three-level combinatorial indexing to >110 samples representing 15 organs, ultimately profiling ~4 million single cells. We leveraged the literature and other atlases to identify and annotate hundreds of cell types and subtypes, both within and across tissues. Our analyses focused on organ-specific specializations of broadly distributed cell types (such as blood, endothelial, and epithelial), sites of fetal erythropoiesis (which notably included the adrenal gland), and integration with mouse developmental atlases (such as conserved specification of blood cells). These data represent a rich resource for the exploration of in vivo human gene expression in diverse tissues and cell types. © 2020 American Association for the Advancement of Science. All rights reserved.
英文关键词	biological development; blood; cell; gene expression; specialization; adrenal gland; animal cell; animal experiment; article; blood cell; chromatin; endothelium; erythropoiesis; fetus; fetus tissue; gene expression; human; in vivo study; male; mouse; nonhuman; protein fingerprinting; specialization; book; cytology; gene expression profiling; gene expression regulation; metabolism; nerve cell; single cell analysis; transcription factor; Atlases as Topic; Chromatin; Fetus; Gene Expression Profiling; Gene Expression Regulation, Developmental; Humans; Neurons; Single-Cell Analysis; Transcription Factors
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/243232
作者单位	Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, United States; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, United States; Brotman Baty Institute for Precision Medicine, Seattle, WA, United States; Department of Pediatrics, University of Rochester Medical Center, Rochester, NY, United States; Center for Data Visualization, Fred Hutchinson Cancer Research Center, Seattle, WA, United States; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, United States; Illumina Inc., San Diego, CA, United States; Human Molecular Genomics Group, Max Planck Institute for Molecular Genetics, Berlin, Germany; Institute of Human Genetics, University of Lübeck, Lübeck, Germany; Allen Discovery Center for Cell Lineage Tracing, Seattle, WA, United States; Howard Hughes Medical Institute, Seattle, WA, United States
推荐引用方式 GB/T 7714	Cao J.,O’Day D.R.,Pliner H.A.,et al. A human cell atlas of fetal gene expression[J],2020,370(6518).
APA	Cao J..,O’Day D.R..,Pliner H.A..,Kingsley P.D..,Deng M..,...&Shendure J..(2020).A human cell atlas of fetal gene expression.Science,370(6518).
MLA	Cao J.,et al."A human cell atlas of fetal gene expression".Science 370.6518(2020).