气候变化领域集成服务门户(CCPortal): DNA sequence–directed shape change of photopatterned hydrogels via high-degree swelling

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DOI	10.1126/science.aan3925
	DNA sequence–directed shape change of photopatterned hydrogels via high-degree swelling
	Cangialosi A.; Yoon C.; Liu J.; Huang Q.; Guo J.; Nguyen T.D.; Gracias D.H.; Schulman R.
发表日期	2017
ISSN	0036-8075
起始页码	1126
结束页码	1130
卷号	357 期号:6356
英文摘要	Shape-changing hydrogels that can bend, twist, or actuate in response to external stimuli are critical to soft robots, programmable matter, and smart medicine. Shape change in hydrogels has been induced by global cues, including temperature, light, or pH. Here we demonstrate that specific DNA molecules can induce 100-fold volumetric hydrogel expansion by successive extension of cross-links. We photopattern up to centimeter-sized gels containing multiple domains that undergo different shape changes in response to different DNA sequences. Experiments and simulations suggest a simple design rule for controlled shape change. Because DNA molecules can be coupled to molecular sensors, amplifiers, and logic circuits, this strategy introduces the possibility of building soft devices that respond to diverse biochemical inputs and autonomously implement chemical control programs. © 2017, American Association for the Advancement of Science. All rights reserved.
英文关键词	DNA; DNA; Article; bilayer membrane; combinatorial library; controlled study; cross linking; DNA sequence; DNA sequence directed shape change; hydrogel; physical phenomena; priority journal; simulation; chemistry; hydrogel; photochemistry; temperature; DNA; Hydrogels; Photochemical Processes; Temperature
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/243227
作者单位	Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, United States; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21218, United States; Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD 21218, United States; Department of Computer Science, Johns Hopkins University, Baltimore, MD 21218, United States
推荐引用方式 GB/T 7714	Cangialosi A.,Yoon C.,Liu J.,等. DNA sequence–directed shape change of photopatterned hydrogels via high-degree swelling[J],2017,357(6356).
APA	Cangialosi A..,Yoon C..,Liu J..,Huang Q..,Guo J..,...&Schulman R..(2017).DNA sequence–directed shape change of photopatterned hydrogels via high-degree swelling.Science,357(6356).
MLA	Cangialosi A.,et al."DNA sequence–directed shape change of photopatterned hydrogels via high-degree swelling".Science 357.6356(2017).